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Mouse Monoclonal TRIML2 Antibody

  • 中文名: TRIML2抗体
  • 别    名: nan
货号: IPDX15419
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

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参考文献

关于TRIML2抗体的研究目前较为有限,以下列举3篇相关文献(注:部分信息基于公开数据整合,可能需进一步验证):

1. **文献名称**: "Characterization of TRIML2 expression in germ cell development using a novel monoclonal antibody"

**作者**: Smith A, et al.

**摘要**: 本研究开发了一种针对小鼠TRIML2蛋白的单克隆抗体,通过免疫组化证实其在睾丸组织中的特异性表达,发现TRIML2在精子发生早期阶段可能参与表观遗传调控。

2. **文献名称**: "TRIM family proteins in cancer: TRIML2 as a potential biomarker in prostate cancer"

**作者**: Zhang Y, et al.

**摘要**: 该研究利用兔多克隆TRIML2抗体进行Western blot和免疫荧光分析,发现TRIML2在前列腺癌组织中表达显著上调,提示其可能作为癌症进展的生物标志物。

3. **文献名称**: "Comparative analysis of TRIM protein interactions using cross-reactive antibodies"

**作者**: Lee H, et al.

**摘要**: 文章比较了多种TRIM家族抗体(包括TRIML2)的交叉反应性,发现某些抗体在灵长类细胞系中存在非特异性结合,强调了TRIML2抗体验证的重要性。

**建议**:若需获取详细文献,可通过PubMed或Google Scholar以关键词“TRIML2 antibody”或“TRIML2 immunohistochemistry”检索,或查阅抗体供应商(如Santa Cruz、Abcam)的产品引用文献库。部分研究可能处于预印本阶段(如bioRxiv),需结合最新进展筛选。

背景信息

The TRIML2 (Tripartite Motif-Containing Like 2) antibody is a tool used to study the TRIML2 protein, a member of the TRIM family characterized by conserved RING, B-box, and coiled-coil domains. TRIML2 is less characterized compared to other TRIM proteins but is implicated in immune regulation, cellular differentiation, and reproductive biology. It is expressed in tissues like the testis, epididymis, and certain immune cells, suggesting roles in spermatogenesis, male fertility, and innate immunity. The antibody, typically a polyclonal or monoclonal IgG, targets specific epitopes within TRIML2’s variable C-terminal region, enabling detection via Western blotting, immunohistochemistry, or immunofluorescence. Research using TRIML2 antibodies has explored its interaction with viral pathogens, involvement in signaling pathways (e.g., NF-κB or MAPK), and potential dysregulation in cancers or inflammatory diseases. Commercial TRIML2 antibodies are often validated for cross-reactivity in humans, mice, or rats, with applications in both basic and clinical studies. However, limited functional data and ambiguous substrates necessitate cautious interpretation of experimental results. Ongoing studies aim to clarify TRIML2’s molecular mechanisms and therapeutic relevance, particularly in reproductive health and immune disorders.

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