Mouse Monoclonal TRIML2 Antibody

The TRIML2 (Tripartite Motif-Containing Like 2) antibody is a tool used to study the TRIML2 protein, a member of the TRIM family characterized by conserved RING, B-box, and coiled-coil domains. TRIML2 is less characterized compared to other TRIM proteins but is implicated in immune regulation, cellular differentiation, and reproductive biology. It is expressed in tissues like the testis, epididymis, and certain immune cells, suggesting roles in spermatogenesis, male fertility, and innate immunity. The antibody, typically a polyclonal or monoclonal IgG, targets specific epitopes within TRIML2’s variable C-terminal region, enabling detection via Western blotting, immunohistochemistry, or immunofluorescence. Research using TRIML2 antibodies has explored its interaction with viral pathogens, involvement in signaling pathways (e.g., NF-κB or MAPK), and potential dysregulation in cancers or inflammatory diseases. Commercial TRIML2 antibodies are often validated for cross-reactivity in humans, mice, or rats, with applications in both basic and clinical studies. However, limited functional data and ambiguous substrates necessitate cautious interpretation of experimental results. Ongoing studies aim to clarify TRIML2’s molecular mechanisms and therapeutic relevance, particularly in reproductive health and immune disorders.