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Mouse Monoclonal PAM Antibody

  • 中文名: PAM抗体
  • 别    名: nan
货号: IPDX15411
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PAM
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于PAM抗体的3篇虚构参考文献示例,格式为文献名称、作者及摘要概括:

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1. **"Autoantibodies Targeting Peptidylglycine α-Amidating Monooxygenase in Autoimmune Neurological Syndromes"**

*作者:Smith, J., et al. (2020)*

**摘要**:研究报道了在部分自身免疫性脑炎患者血清中发现PAM抗体,提示其可能与突触功能异常相关,为神经免疫疾病的诊断提供了新标记物。

2. **"Structural and Functional Analysis of PAM Enzyme Catalytic Domains"**

*作者:Eipper, B.A., et al. (1992)*

**摘要**:早期研究阐明了PAM酶的双催化结构域机制及其在神经肽(如促甲状腺激素释放激素)生物合成中的关键作用,为后续抗体开发奠定基础。

3. **"PAM Expression and Its Clinical Significance in Neuroendocrine Tumors"**

*作者:Kumar, A., et al. (2018)*

**摘要**:通过免疫组化分析,发现PAM在胃肠胰神经内分泌肿瘤中高表达,其特异性抗体可用于病理诊断及预后评估。

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*注:上述文献为示例性质,实际研究中建议通过PubMed或Google Scholar检索真实文献。*

背景信息

**Background of PAM Antibodies**

PAM (anti-aminoacyl-tRNA synthetase) antibodies are a group of autoantibodies targeting aminoacyl-tRNA synthetases, enzymes essential for protein synthesis by attaching amino acids to their corresponding tRNA molecules. These antibodies are strongly associated with idiopathic inflammatory myopathies (IIM), particularly polymyositis and dermatomyositis, and are a hallmark of antisynthetase syndrome—a clinical condition characterized by myositis, interstitial lung disease, arthritis, Raynaud’s phenomenon, and mechanic’s hands.

First identified in the 1980s, the most common PAM antibody is anti-Jo-1 (targeting histidyl-tRNA synthetase), accounting for ~80% of cases. Other subtypes (e.g., anti-PL-7. anti-PL-12) target different synthetases and exhibit varying clinical associations. Their pathogenesis remains unclear but may involve molecular mimicry, environmental triggers (e.g., viral infections), or genetic predisposition (e.g., HLA-DR alleles).

PAM antibodies aid in diagnosis, prognosis, and subtyping of IIM. Patients with these antibodies often have aggressive interstitial lung disease, influencing treatment strategies. Detection methods include immunoprecipitation, ELISA, or line immunoassays. Despite their clinical utility, the direct role of these autoantibodies in tissue damage—whether pathogenic or bystanders—requires further study. Research continues to explore targeted therapies to modulate immune responses against synthetases.

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