| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CAPG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CAPG抗体的3篇参考文献概览(注：文献信息为虚构示例，仅作格式参考)：
1. **《CAPG as a biomarker in breast cancer progression》**
- 作者：Smith A, et al.
- 摘要：研究揭示了CAPG蛋白在乳腺癌转移中的关键作用，通过特异性抗体检测发现CAPG高表达与患者预后不良相关，提示其可作为潜在治疗靶点。
2. **《Development of a novel anti-CAPG monoclonal antibody for diagnostic applications》**
- 作者：Lee J, et al.
- 摘要：报道了一种新型CAPG单克隆抗体的开发，验证了其在免疫组化中的高特异性，可用于区分肿瘤与正常组织，提升病理诊断准确性。
3. **《CAPG regulates cytoskeletal dynamics and promotes invasion in prostate cancer》**
- 作者：Wang Y, et al.
- 摘要：利用CAPG抗体进行功能研究，发现其通过调控肌动蛋白重塑促进前列腺癌细胞侵袭，抑制CAPG可降低转移潜能。
如需真实文献，建议通过PubMed或Google Scholar以“CAPG antibody”、“CAPG biomarker”等关键词检索近年研究。
CAPG (macrophage-capping protein) is a cytoskeletal regulatory protein belonging to the gelsolin superfamily. It modulates actin dynamics by capping the barbed ends of actin filaments, influencing cell motility, membrane remodeling, and intracellular signaling. Primarily localized in the cytoplasm, CAPG also shuttles to the nucleus, where its role remains less defined but may involve gene regulation.
CAPG antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. Research highlights CAPG's overexpression in various cancers, including breast, prostate, and colorectal carcinomas, where it promotes tumor cell invasion, metastasis, and epithelial-mesenchymal transition (EMT). Antibodies enable detection of CAPG in clinical samples, linking its levels to disease progression and patient prognosis.
In immunology, CAPG is implicated in macrophage-mediated inflammation and immune responses. Antibodies help explore its interaction with cytoskeletal components in immune cell migration and phagocytosis. Additionally, CAPG autoantibodies have been reported in autoimmune diseases, suggesting diagnostic potential.
Commercial CAPG antibodies are widely used in techniques like Western blot, immunofluorescence, and IHC. Challenges include ensuring isoform specificity, as CAPG shares homology with other gelsolin-family proteins. Ongoing studies aim to clarify CAPG's dual roles in cancer suppression/promotion and its therapeutic targeting potential.
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