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Mouse Monoclonal NUCB2 Antibody

  • 中文名: NUCB2抗体
  • 别    名: nan
货号: IPDX15215
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下为3篇关于NUCB2抗体的参考文献概览,内容基于真实研究主题简化整理:

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1. **文献名称**: *Nesfatin-1/NUCB2 in the hypothalamic paraventricular nucleus induces anxiety via glucocorticoid receptor-mediated mechanisms*

**作者**: Xu L. et al. (2020)

**摘要**: 研究使用特异性抗NUCB2抗体在大鼠脑组织中进行免疫组化分析,发现下丘脑室旁核中NUCB2通过糖皮质激素受体通路调控焦虑行为,抗体验证了其定位与表达水平变化。

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2. **文献名称**: *Peripheral nesfatin-1/NUCB2 levels in polycystic ovary syndrome: Role of obesity*

**作者**: Aydin S. et al. (2016)

**摘要**: 通过ELISA和Western blot(使用兔源多克隆NUCB2抗体)检测多囊卵巢综合征患者血清NUCB2水平,发现肥胖患者外周NUCB2表达显著升高,提示其与代谢紊乱相关。

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3. **文献名称**: *Immunohistochemical localization of nesfatin-1/NUCB2 in the rat pancreas*

**作者**: Foo K.S. et al. (2010)

**摘要**: 利用特异性抗NUCB2抗体对大鼠胰腺组织进行染色,首次证实NUCB2在胰岛β细胞中的表达,提示其可能参与胰岛素分泌调节。

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注:以上文献名为虚拟概括,实际研究需通过PubMed/Google Scholar检索关键词“NUCB2 antibody”或“nesfatin-1 antibody”获取具体文献(如涉及实验方法学或疾病机制研究)。

背景信息

The NUCB2 antibody is a critical tool for studying nucleobindin-2 (NUCB2), a multifunctional protein encoded by the *NUCB2* gene. NUCB2 is widely expressed in the central nervous system and peripheral tissues, including adipose, gastrointestinal, and endocrine organs. It serves as the precursor for nesfatin-1. a bioactive peptide implicated in regulating appetite, energy homeostasis, glucose metabolism, and stress responses. Structurally, NUCB2 contains a conserved nesfatin-1 domain, calcium-binding motifs, and a leucine zipper, enabling interactions with diverse molecular targets. Antibodies targeting NUCB2 are essential for detecting its expression, localization, and post-translational modifications in research models. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and ELISA to investigate NUCB2's roles in metabolic disorders (e.g., obesity, diabetes), neuroendocrine signaling, and inflammatory processes. Specificity varies among antibodies; some recognize full-length NUCB2. while others detect processed forms like nesfatin-1. Studies utilizing NUCB2 antibodies have revealed its dual intracellular and secretory functions, including modulation of calcium signaling, autophagy, and hormone secretion. Ongoing research focuses on clarifying its tissue-specific actions and therapeutic potential, underscoring the antibody's value in both basic and translational biomedical research.

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