| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CDHR5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于CDHR5抗体的模拟参考文献示例(非真实文献，仅供格式参考)：
1. **文献名称**：CDHR5 as a novel biomarker in colorectal cancer: Antibody development and clinical validation
**作者**：Smith J, et al.
**摘要**：研究团队开发了一种高特异性抗CDHR5单克隆抗体，并通过免疫组化验证其在结直肠癌组织中高表达，证实CDHR5与肿瘤转移相关。
2. **文献名称**：Anti-CDHR5 antibody-mediated targeting inhibits pancreatic tumor growth in murine models
**作者**：Chen L, et al.
**摘要**：利用抗CDHR5抗体偶联药物进行靶向治疗实验，结果显示抗体能特异性识别胰腺癌细胞表面CDHR5.显著抑制小鼠模型肿瘤生长。
3. **文献名称**：Comparative analysis of CDHR5 expression in normal and cancerous lung tissues using novel polyclonal antibodies
**作者**：Wang Y, et al.
**摘要**：通过制备兔源多克隆抗体，发现CDHR5在非小细胞肺癌组织中的表达水平显著高于正常肺组织，提示其作为诊断标志物的潜力。
4. **文献名称**：Structural characterization of CDHR5 extracellular domain and its antibody interaction sites
**作者**：Kim S, et al.
**摘要**：利用X射线晶体学解析CDHR5胞外域结构，并鉴定出抗CDHR5抗体的关键结合表位，为抗体药物优化提供结构基础。
**提示**：以上为模拟文献，实际研究中建议通过PubMed或Web of Science检索真实文献(关键词：CDHR5 antibody, Cadherin-Related Family Member 5)。CDHR5研究多集中于上皮细胞极性调控、癌症转移及病毒受体等领域。
**Background of CDHR5 Antibody**
CDHR5 (Cadherin-Related Family Member 5), also known as protocadherin-24. is a calcium-dependent cell adhesion protein belonging to the cadherin superfamily. It is primarily expressed in epithelial tissues, particularly in the kidney, intestine, and lung, where it plays a role in maintaining cell-cell adhesion and tissue integrity. Structurally, CDHR5 contains multiple extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail, though its exact signaling mechanisms remain less characterized compared to classical cadherins like E-cadherin.
CDHR5 antibodies are tools developed to detect and study the expression, localization, and function of this protein. Research has linked CDHR5 to epithelial polarization, barrier formation, and potential roles in disease contexts. For instance, altered CDHR5 expression has been observed in certain cancers, suggesting its involvement in tumor progression or metastasis. Additionally, CDHR5 is studied in renal and gastrointestinal pathologies, where epithelial dysfunction is a hallmark.
These antibodies are widely used in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to explore CDHR5's biological significance. Their development has facilitated insights into epithelial cell biology and provided a foundation for investigating CDHR5 as a diagnostic or therapeutic target in diseases involving epithelial integrity loss. Further studies are needed to fully elucidate its molecular interactions and clinical relevance.
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