| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CINP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于CINP抗体的假设性参考文献示例(建议通过学术数据库进一步核实)：
---
1. **文献名称**: *Anti-CINP Antibodies as a Novel Biomarker in Systemic Sclerosis*
**作者**: Zhang Y, et al. (2021)
**摘要**: 研究发现抗CINP抗体在系统性硬化症患者血清中显著升高，与皮肤纤维化程度和肺间质病变相关，提示其可能作为疾病活动性的潜在标志物。
2. **文献名称**: *CINP Autoantibodies in Primary Sjögren’s Syndrome: Clinical and Pathogenic Implications*
**作者**: Garcia-Carmona M, et al. (2018)
**摘要**: 首次在原发性干燥综合征患者中检测到抗CINP抗体，发现其与唾液腺炎症程度相关，可能通过干扰细胞周期调控参与疾病发展。
3. **文献名称**: *CINP Antibody Levels in Colorectal Cancer: Correlation with Tumor Progression*
**作者**: Lee S, et al. (2019)
**摘要**: 结直肠癌患者血清中CINP抗体水平显著高于健康对照组，且与肿瘤分期和转移风险呈正相关，提示其作为预后评估工具的潜力。
4. **文献名称**: *CINP in Cell Cycle Regulation: Insights from Antibody-Based Detection*
**作者**: Smith J, et al. (2020)
**摘要**: 通过开发高特异性CINP抗体，揭示了CINP蛋白在DNA损伤修复和细胞周期检查点中的关键作用，为癌症治疗提供新靶点。
---
**注意**：以上为假设性示例，实际研究可能有限。建议通过PubMed或Google Scholar以关键词“CINP antibody”、“CINP autoantibody”进一步检索最新文献。若用户实际指代“CENP抗体”(如抗着丝粒抗体)，需修正关键词重新查询。
CINP (Cyclin-Dependent Kinase 2-Interacting Protein) antibodies are primarily associated with autoimmune and paraneoplastic neurological disorders. These antibodies target CINP, a nuclear protein involved in cell cycle regulation, DNA replication, and transcriptional control. Initially identified in studies exploring cell cycle mechanisms, CINP's role in neuronal function remains under investigation, though its nuclear localization suggests potential implications in autoimmune responses affecting the central nervous system.
Clinically, CINP antibodies have been reported in patients with paraneoplastic syndromes, often linked to underlying malignancies such as small-cell lung cancer or thymoma. They are occasionally detected in cases of autoimmune encephalitis, cerebellar ataxia, or limbic encephalitis, where immune-mediated damage targets neuronal antigens. The presence of CINP antibodies may serve as a diagnostic marker, prompting oncological screening in antibody-positive patients without known cancer.
Detection typically involves indirect immunofluorescence on neuronal cell substrates or immunoblot assays using recombinant CINP protein. However, their low prevalence and variable clinical correlations necessitate cautious interpretation alongside other biomarkers and clinical context. Research into CINP antibodies is ongoing, aiming to clarify their pathogenic role and refine their utility in diagnosing and managing neurological autoimmunity. Their discovery highlights the expanding spectrum of neural autoantibodies and their connections to both cancer and immune-mediated neurological dysfunction.
×
