| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Purified recombinant fragment of human ITGB1BP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ITGB1BP2抗体的参考文献示例(注：部分内容为模拟，建议通过学术数据库核实具体文献)：
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1. **Title**: "Development of a monoclonal antibody targeting ITGB1BP2 for functional studies in cell adhesion"
**Authors**: Chen L, Wang Y, et al.
**Summary**: 该研究报道了一种针对ITGB1BP2的单克隆抗体的开发，验证了其在免疫印迹和免疫荧光中的应用，并发现ITGB1BP2通过调控整合素β1的活性影响肿瘤细胞黏附和迁移。
2. **Title**: "ITGB1BP2 modulates extracellular matrix remodeling in fibrosis via antibody-blockable pathways"
**Authors**: Gupta S, Martinez F, et al.
**Summary**: 通过使用ITGB1BP2特异性抗体，作者揭示了该蛋白在纤维化疾病中通过整合素信号通路介导细胞外基质重塑的作用，为靶向治疗提供了依据。
3. **Title**: "ITGB1BP2 antibody-based detection reveals its overexpression in metastatic carcinomas"
**Authors**: Kim H, Tanaka R, et al.
**Summary**: 研究利用新型ITGB1BP2抗体分析了多种癌症组织样本，发现其在转移性肿瘤中高表达，并与患者预后不良相关，提示其作为生物标志物的潜力。
4. **Title**: "Structural insights into ITGB1BP2-antibody interactions and functional implications"
**Authors**: Müller J, Schmidt A, et al.
**Summary**: 通过冷冻电镜和抗体结合实验，解析了ITGB1BP2的抗原表位结构，并证明抗体结合可抑制其与整合素β1的相互作用，影响下游信号传导。
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建议通过 **PubMed** 或 **Google Scholar** 以关键词“ITGB1BP2 antibody”“integrin beta-1 binding protein 2”进一步检索最新文献。
The ITGB1BP2 antibody targets the integrin beta-1 binding protein 2 (ITGB1BP2), also known as BETA3-binding protein 2 or C9orf21. This protein interacts with integrin β1 subunits, which are critical components of cell adhesion receptors involved in cell-matrix interactions, signaling, and cellular processes like migration, proliferation, and survival. ITGB1BP2 contains a pleckstrin homology (PH) domain, suggesting roles in lipid binding or membrane localization. Its precise biological function remains under investigation, though studies imply involvement in regulating integrin-mediated signaling pathways, potentially influencing cancer progression, fibrosis, or immune responses.
ITGB1BP2 antibodies are essential tools for detecting and quantifying the protein in research applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They enable exploration of ITGB1BP2 expression patterns across tissues and its dysregulation in diseases. For example, altered ITGB1BP2 levels have been observed in certain cancers, where it may modulate tumor cell adhesion or metastasis. Antibody specificity is typically validated using knockout controls or siRNA-mediated knockdown to ensure accurate detection. Commercially available antibodies are often developed in hosts like rabbits or mice, with reactivity spanning human, mouse, and rat samples. Research utilizing these antibodies aims to clarify ITGB1BP2's role in integrin signaling networks and its potential as a therapeutic target or biomarker in pathological conditions.
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