| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BLOC1S2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于BLOC1S2抗体的3篇模拟参考文献示例(基于领域内典型研究方向，非真实文献)：
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1. **文献名称**：*BLOC1S2 as a critical component of the BLOC-1 complex in lysosome-related organelle biogenesis*
**作者**：Dell'Angelica EC, et al.
**摘要**：本研究阐明了BLOC1S2作为BLOC-1复合物的核心亚基，在溶酶体相关细胞器(如黑素体、血小板致密颗粒)形成中的作用。通过免疫共沉淀和抗体标记实验，证实其与BLOC-1其他亚基的相互作用，并揭示了其在细胞内囊泡运输中的调控机制。
2. **文献名称**：*Mutation analysis of BLOC1S2 in Hermansky-Pudlak syndrome patients using a novel polyclonal antibody*
**作者**：Wei ML, et al.
**摘要**：开发了一种针对BLOC1S2的多克隆抗体，用于检测Hermansky-Pudlak综合征(HPS)患者的蛋白表达缺失。通过Western blot和免疫荧光，发现BLOC1S2基因突变导致BLOC-1复合体功能异常，从而解释了部分HPS亚型的病理机制。
3. **文献名称**：*BLOC1S2 antibody application in tracking protein dynamics during melanosome maturation*
**作者**：Smith TJ, et al.
**摘要**：利用BLOC1S2特异性抗体，通过活细胞成像技术揭示了该蛋白在黑素体成熟过程中的动态定位变化。研究表明，BLOC1S2的缺失会中断黑素体内酪氨酸酶运输，导致色素沉积缺陷。
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**注**：以上文献为模拟示例，实际研究中建议通过PubMed或Google Scholar检索真实文献(关键词：BLOC1S2 antibody, BLOC-1 complex, HPS)。
The BLOC1S2 antibody is designed to detect BLOC1S2 (Biogenesis of Lysosome-Related Organelles Complex 1 Subunit 2), a protein component of the BLOC-1 complex. This multisubunit complex plays a critical role in the biogenesis and trafficking of lysosome-related organelles (LROs), including melanosomes, platelet dense granules, and synaptic vesicles. BLOC1S2. encoded by the BLOC1S2 gene, contributes to the structural integrity of the BLOC-1 complex, facilitating interactions with other trafficking regulators like AP-3 and kinesin motors.
Antibodies targeting BLOC1S2 are widely used in research to study LRO formation and their associated disorders. Mutations in BLOC-1 subunits, including BLOC1S2. are linked to Hermansky-Pudlak syndrome (HPS), a rare autosomal recessive disorder characterized by oculocutaneous albinism, bleeding diathesis, and sometimes immunodeficiency or neurodegeneration. BLOC1S2 antibodies enable the detection of protein expression levels, subcellular localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation.
These tools have also shed light on BLOC1S2’s broader roles beyond HPS, including potential involvement in neuronal development, synaptic plasticity, and diseases such as schizophrenia. Researchers rely on BLOC1S2 antibodies to explore molecular mechanisms underlying organelle biogenesis and trafficking defects, offering insights into therapeutic strategies for related pathologies.
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