| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT149 |
| WB Predicted band size | 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TEKT5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TEKT5抗体的3篇参考文献示例(部分信息为模拟整理，仅供参考)：
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1. **文献名称**: *Tektin5 deficiency affects sperm flagellum assembly and male fertility in mice*
**作者**: Li W, et al.
**摘要**: 本研究利用针对TEKT5的特异性抗体，揭示了TEKT5在小鼠精子尾部组装中的关键作用。通过免疫荧光和Western blot分析，发现TEKT5缺失导致精子运动能力受损，为男性不育机制提供了新见解。
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2. **文献名称**: *Characterization of TEKT5 expression in human ciliated tissues using a novel monoclonal antibody*
**作者**: Smith J, et al.
**摘要**: 文章报道了一种新型抗人TEKT5单克隆抗体的开发与验证。该抗体被用于免疫组化分析，显示TEKT5在呼吸道纤毛上皮细胞中高表达，提示其可能参与纤毛功能障碍相关疾病。
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3. **文献名称**: *Proteomic analysis of TEKT5 interaction networks in spermatogenesis*
**作者**: Chen H, et al.
**摘要**: 通过TEKT5抗体进行免疫共沉淀和质谱分析，鉴定出多个与TEKT5相互作用的精子发生相关蛋白，表明其在减数分裂和鞭毛形成中具有调控功能。
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**备注**：上述文献为示例，实际引用时请通过PubMed或专业数据库(如Google Scholar)核对真实文献信息。
The TEKT5 antibody targets TEKTIN5. a member of the tektin family of filamentous proteins critical for maintaining structural integrity in cilia, flagella, and centrosomes. Tektins, including TEKT5. are evolutionarily conserved and share homology with intermediate filament proteins. TEKT5 is specifically expressed in germ cells and localizes to the manchette, a transient microtubule-based structure essential for sperm head shaping during spermatogenesis. Its role in sperm development has linked TEKT5 mutations or dysregulation to male infertility in both humans and animal models. Additionally, TEKT5 has been implicated in ciliary function and mitotic spindle organization, suggesting broader cellular roles beyond reproduction.
TEKT5 antibodies are widely used in reproductive biology research to study sperm maturation, flagellar assembly, and germ cell-specific molecular mechanisms. These antibodies enable detection of TEKT5 expression patterns via techniques like immunohistochemistry, Western blotting, and immunofluorescence. Commercially available TEKT5 antibodies are typically raised against specific epitopes, often in rabbits or mice, with validation in model organisms such as mice and rats. Recent studies also explore TEKT5's potential involvement in cancer, as abnormal expression has been observed in certain tumors. However, its precise oncogenic mechanisms remain under investigation. As a research tool, TEKT5 antibodies continue to advance understanding of gametogenesis, ciliopathies, and cellular structural dynamics.
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