Rabbit Polyclonal RARA Antibody

The retinoic acid receptor alpha (RARA) antibody is a tool used to detect the RARA protein, a member of the nuclear receptor superfamily that regulates gene expression in response to retinoic acid (RA). RARA plays a critical role in cellular differentiation, proliferation, and apoptosis by binding to RA and forming heterodimers with retinoid X receptors (RXRs) to activate target genes. Dysregulation of RARA is most notably linked to acute promyelocytic leukemia (APL), where a chromosomal translocation t(15;17) fuses RARA with the PML gene, producing an oncogenic PML-RARA fusion protein. This fusion disrupts normal RA signaling, blocks myeloid differentiation, and promotes leukemogenesis. Antibodies targeting RARA are essential in diagnostic pathology to confirm APL via immunohistochemistry (IHC) or Western blot, distinguishing it from other leukemias. They also aid in research to study RA pathway dynamics, drug resistance mechanisms (e.g., ATRA resistance in APL), and therapeutic responses. Additionally, RARA antibodies contribute to understanding RARA's roles in non-cancer contexts, such as development, immune regulation, and epithelial homeostasis. Their application extends to monitoring minimal residual disease (MRD) and evaluating novel therapies targeting RARA-dependent pathways. Overall, RARA antibodies are vital for both clinical management and molecular research in oncology and beyond.