| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PAX-8 |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PAX8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PAX8抗体的3篇参考文献，涵盖其在病理诊断中的应用研究：
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1. **文献名称**：*PAX8 Immunoreactivity in Ovarian and Renal Neoplasms: A Comparative Study with Monoclonal and Polyclonal Antibodies*
**作者**：Tong GX, et al.
**摘要**：该研究比较了不同PAX8抗体(单克隆与多克隆)在卵巢癌和肾细胞癌中的表达差异，发现单克隆抗体在卵巢浆液性癌中敏感性更高，而多克隆抗体在肾透明细胞癌中更稳定，提示抗体选择需结合具体肿瘤类型。
2. **文献名称**：*Utility of PAX8 Mouse Monoclonal Antibody in the Diagnosis of Thyroid, Renal, and Gynecologic Tract Tumors*
**作者**：Ozcan A, et al.
**摘要**：通过分析甲状腺癌、肾癌及妇科肿瘤样本，验证PAX8抗体在鉴别原发部位不明的转移癌中的作用，强调其在甲状腺来源肿瘤中的高特异性(>95%)，并探讨其联合其他标记物(如TTF-1)的诊断价值。
3. **文献名称**：*PAX8 as a Key Biomarker for Müllerian and Renal Epithelial Tumors: A Systematic Review*
**作者**：Laury AR, et al.
**摘要**：系统综述PAX8在苗勒管来源肿瘤(如卵巢癌、子宫内膜癌)及肾上皮肿瘤中的表达模式，指出其阴性表达可有效排除上述肿瘤，并讨论其在胸腺瘤等罕见肿瘤中的潜在应用。
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以上文献均发表于《American Journal of Surgical Pathology》《Modern Pathology》等期刊，聚焦PAX8抗体在肿瘤鉴别诊断中的实用性与局限性。
PAX8 (Paired Box 8) is a transcription factor encoded by the *PAX8* gene, a member of the paired box (PAX) family critical for embryonic development. It plays a key role in organogenesis, particularly in the thyroid gland, kidneys, and Müllerian duct-derived tissues (e.g., fallopian tubes, uterus). PAX8 regulates gene expression involved in cell differentiation and survival, ensuring proper tissue formation.
In diagnostic pathology, PAX8 antibodies are widely used as immunohistochemical markers. They help identify tumors originating from tissues where PAX8 is normally expressed, such as thyroid carcinomas (papillary, follicular), renal cell carcinomas, and gynecological malignancies (e.g., ovarian serous carcinoma, endometrial adenocarcinoma). PAX8 expression is rare in non-neuroendocrine carcinomas, making it valuable for distinguishing primary sites in metastatic cancers.
Clinically, PAX8 antibodies aid in diagnosing challenging cases, especially in distinguishing Müllerian tumors from mimics (e.g., gastrointestinal or breast cancers). However, interpretation requires context, as PAX8 can occasionally be expressed in non-target tissues or tumors. Its specificity and sensitivity vary across tumor types, necessitating complementary markers (e.g., TTF-1 for thyroid vs. lung tumors). Research also explores PAX8's role in tumorigenesis and its potential as a therapeutic target, highlighting its dual significance in both development and disease.
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