| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HELO1; SCA38; dJ483K16.1 |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ELOVL5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ELOVL5抗体的参考文献概览：
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1. **标题**: *"ELOVL5-mediated fatty acid elongation regulates cellular proliferation in human hepatocellular carcinoma"*
**作者**: Zhang Y, et al.
**摘要**: 该研究使用特异性ELOVL5抗体进行Western blot和免疫组化分析，发现ELOVL5在肝癌组织中高表达，并通过调控多不饱和脂肪酸合成促进肿瘤细胞增殖，提示其作为肝癌潜在治疗靶点。
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2. **标题**: *"Tissue-specific expression of ELOVL5 in mouse models of metabolic syndrome"*
**作者**: Brown KE, et al.
**摘要**: 通过ELOVL5抗体对小鼠肝脏、脂肪组织的免疫荧光检测，揭示ELOVL5在高脂饮食诱导的代谢综合征模型中表达上调，与脂质代谢紊乱和胰岛素抵抗相关。
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3. **标题**: *"ELOVL5 mutations impair lipid homeostasis in neurodegenerative disorders"*
**作者**: García-Serrano A, et al.
**摘要**: 研究利用ELOVL5抗体结合免疫印迹技术，发现携带ELOVL5突变患者的成纤维细胞中长链脂肪酸水平异常，表明其突变通过干扰脂质稳态参与神经退行性疾病病理。
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**备注**：上述文献为示例，实际引用时需核实数据库(如PubMed)中的具体信息，确保作者、标题及摘要内容准确性。
The ELOVL5 (Elongation of Very Long Chain Fatty Acids 5) antibody is a research tool designed to detect and study the ELOVL5 protein, a member of the ELOVL family of enzymes critical in the elongation of polyunsaturated fatty acids (PUFAs). ELOVL5 specifically catalyzes the elongation of C18 and C20 PUFAs to form very long-chain fatty acids (VLCFAs, up to C24), which are essential components of cellular membranes, signaling molecules, and precursors for bioactive lipids. Dysregulation of ELOVL5 has been implicated in metabolic disorders, neurodegenerative diseases, and cancers, making it a target for investigating lipid metabolism pathways and disease mechanisms.
ELOVL5 antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression levels, localization, and tissue distribution. Studies utilizing these antibodies have revealed ELOVL5's role in hepatic lipid homeostasis, retinal function, and neuronal health. For instance, reduced ELOVL5 expression is linked to non-alcoholic fatty liver disease (NAFLD), while its overexpression in certain cancers correlates with tumor progression and poor prognosis.
The development and validation of ELOVL5 antibodies are crucial for understanding its physiological and pathological functions. Researchers also explore its potential as a biomarker or therapeutic target, particularly in metabolic syndromes and cancers. However, challenges remain in standardizing antibody specificity across experimental models, necessitating careful validation to ensure accurate detection in diverse biological contexts.
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