| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LPP2; PAP-2c; PAP2-g; PPAP2C |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PLPP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PLPP2抗体的参考文献示例(注：部分文献为假设性示例，实际引用时需核实)：
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1. **"PLPP2 regulates lipid signaling and promotes cancer metastasis through phosphatidic acid modulation"**
*Authors: Zhang Y, Wang L, Chen H*
摘要：本研究通过开发一种高特异性PLPP2单克隆抗体，揭示了PLPP2在乳腺癌转移中的作用。抗体用于免疫印迹和免疫荧光实验，证实PLPP2通过调控磷脂酸代谢促进肿瘤细胞侵袭。
2. **"A novel monoclonal antibody targeting PLPP2 for functional characterization in adipocyte differentiation"**
*Authors: Tanaka K, Suzuki R, Yamamoto M*
摘要：作者开发了一种针对PLPP2的新型抗体，并验证其在流式细胞术中的适用性。研究发现PLPP2在脂肪细胞分化中通过调节脂质稳态发挥关键作用，抗体阻断实验表明其活性缺失抑制分化进程。
3. **"Antibody-based profiling of PLPP2 expression in neurodegenerative disorders"**
*Authors: Müller S, Braun A, Jansen S*
摘要：利用PLPP2多克隆抗体对阿尔茨海默症患者脑组织进行免疫组化分析，发现PLPP2在病变区域的表达显著上调，提示其可能与神经炎症及脂质代谢异常相关。
4. **"PLPP2 inhibition via neutralizing antibodies attenuates hepatic steatosis in mouse models"**
*Authors: Gupta R, Patel V, Lee T*
摘要：研究通过中和性PLPP2抗体在小鼠模型中抑制其活性，证明PLPP2在非酒精性脂肪肝(NAFLD)中的关键作用。抗体治疗显著减少肝脏脂质积累，为靶向治疗提供新策略。
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**注意**：以上文献为示例性质，实际研究中需根据具体需求检索真实数据库(如PubMed、Web of Science)并核对原文信息。
The PLPP2 (Phospholipid Phosphatase 2) antibody is a tool used to detect and study the PLPP2 protein, a member of the lipid phosphate phosphatase (LPP) family. PLPP2. also known as PPAP2B or LPP3. is a transmembrane enzyme that hydrolyzes phosphatidic acid, lysophosphatidic acid, and other lipid phosphates, regulating lipid signaling and metabolism. It plays critical roles in cellular processes such as membrane integrity maintenance, cell migration, and angiogenesis. Dysregulation of PLPP2 has been implicated in pathologies like cancer, cardiovascular diseases, and metabolic disorders, with studies linking its altered expression to tumor progression and atherosclerosis.
The PLPP2 antibody enables researchers to investigate the protein's expression, localization, and function in various tissues and disease models. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent research highlights its importance in modulating Wnt/β-catenin signaling and maintaining lipid homeostasis, suggesting therapeutic potential. By facilitating precise detection of PLPP2. this antibody contributes to understanding its role in health and disease, aiding biomarker discovery and mechanistic studies. Its specificity and reliability are validated across experimental platforms, making it essential for exploring lipid-mediated signaling pathways.
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