| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IA4; CD49D |
| Entrez GeneID | 3676 |
| clone | 5C4 |
| WB Predicted band size | 115kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ITGA4 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IL1RAPL2抗体的3篇代表性文献的简要总结(注：文献为虚拟示例，实际研究中可能需结合具体数据库检索)：
1. **文献名称**: *IL1RAPL2 regulates neuronal development and synaptic plasticity via antibody-targeted pathways*
**作者**: Smith A, et al.
**摘要**: 研究通过开发特异性IL1RAPL2抗体，揭示了该蛋白在神经元突触形成中的作用，发现其缺失与X连锁智力障碍相关，抗体阻断实验表明其通过调控MAPK信号通路影响突触功能。
2. **文献名称**: *Characterization of a monoclonal antibody against IL1RAPL2 for cancer immunotherapy*
**作者**: Lee JH, et al.
**摘要**: 文章报道了一种新型IL1RAPL2单克隆抗体的开发，验证其在肿瘤微环境中的高表达，体外实验显示该抗体通过抑制IL-1信号通路增强T细胞抗肿瘤活性，提示其潜在免疫治疗价值。
3. **文献名称**: *IL1RAPL2 antibody-based biomarker panel for autoimmune disease diagnosis*
**作者**: Garcia R, et al.
**摘要**: 研究利用IL1RAPL2抗体结合其他标志物构建诊断模型，发现IL1RAPL2在类风湿性关节炎患者血清中显著上调，抗体检测可用于疾病活动度评估及个性化治疗指导。
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建议通过PubMed或Web of Science以关键词“IL1RAPL2 antibody”、“IL1RAPL2 function”检索最新研究，或关注《Journal of Immunology》《Cell Reports》等期刊的相关论文。
The IL1RAPL2 antibody targets the interleukin-1 receptor accessory protein-like 2 (IL1RAPL2), a protein encoded by the *IL1RAPL2* gene located on the X chromosome. IL1RAPL2 belongs to the interleukin-1 receptor (IL-1R) family but lacks a canonical intracellular signaling domain, suggesting a regulatory role in immune or neural pathways. It is predominantly expressed in the brain, particularly in neurons, and has been implicated in neurodevelopment, synaptic plasticity, and cognitive function. Mutations or deletions in *IL1RAPL2* are associated with X-linked intellectual disability (XLID), autism spectrum disorders (ASD), and neuropsychiatric conditions, highlighting its importance in neural circuit formation and function.
The IL1RAPL2 antibody is a critical tool for studying the protein's expression, localization, and interaction partners in biological samples. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate IL1RAPL2’s role in neuronal development and disease mechanisms. Research using this antibody has helped elucidate its involvement in pathways like MAPK/ERK signaling and its interaction with presynaptic proteins such as PTPδ, which regulates synapse formation. By enabling precise detection, the antibody supports efforts to unravel molecular defects underlying neurodevelopmental disorders and explore potential therapeutic targets.
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