| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MTIF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MTIF2抗体的3篇参考文献的简要列举(注：文献为示例性虚构内容，仅供参考格式)：
1. **文献名称**：*MTIF2 is essential for mitochondrial translation in human cells*
**作者**：Zhang Y, et al.
**摘要**：本研究通过Western blot和免疫荧光技术，利用MTIF2特异性抗体，证实了MTIF2在线粒体翻译起始中的关键作用，并发现其缺失导致线粒体呼吸链复合物合成受损。
2. **文献名称**：*Dysregulation of MTIF2 in Parkinson’s disease models*
**作者**：Chen L, et al.
**摘要**：文章通过MTIF2抗体检测帕金森病模型中该蛋白的表达水平，发现MTIF2下调与线粒体功能障碍相关，提示其可能成为神经退行性疾病的治疗靶点。
3. **文献名称**：*MTIF2 interacts with mitochondrial ribosomes: evidence from co-immunoprecipitation assays*
**作者**：Wang H, et al.
**摘要**：利用MTIF2抗体进行免疫共沉淀实验，揭示了MTIF2与线粒体核糖体亚基的相互作用，并阐明了其在翻译复合体组装中的分子机制。
(注：以上文献为模拟生成，实际研究中请通过学术数据库核实具体信息。)
The MTIF2 (Mitochondrial Translation Initiation Factor 2) antibody is a research tool designed to detect and study the MTIF2 protein, a critical component of mitochondrial translation machinery. MTIF2. also known as IF2mt, plays a pivotal role in initiating protein synthesis within mitochondria by facilitating the assembly of ribosomal subunits and positioning the initiator tRNA on the mitochondrial ribosome. This factor is essential for the translation of mitochondrial DNA (mtDNA)-encoded proteins, which are vital for oxidative phosphorylation and cellular energy production. Dysregulation of mitochondrial translation is linked to metabolic disorders, neurodegenerative diseases, and cancer, making MTIF2 a focus in studying mitochondrial dysfunction.
The MTIF2 antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to evaluate MTIF2 expression levels, subcellular localization, and interactions in various biological samples. It helps researchers investigate mitochondrial protein synthesis dynamics, tissue-specific expression patterns, and disease-associated alterations. Many commercially available MTIF2 antibodies are developed in host species like rabbits or mice, validated for specificity through knockdown/knockout controls or peptide blocking assays. Its applications extend to exploring mitochondrial disorders, aging-related pathologies, and therapeutic responses in preclinical models. Proper validation and optimization are critical due to potential cross-reactivity with homologous proteins or tissue-specific isoforms.
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