| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CSPG2; ERVR; GHAP; PGM; VCAN; Versican; WGN1;;VCAN |
| WB Predicted band size | 373 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human VCAN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ELP1抗体的3篇参考文献示例(文献信息为模拟虚构，供参考)：
1. **文献名称**：*ELP1/IkAP Antibody Characterization in Familial Dysautonomia Models*
**作者**：Smith A, et al.
**摘要**：本研究利用ELP1特异性抗体，通过免疫印迹和免疫组化分析家族性自主神经失调症(FD)患者细胞模型，揭示了ELP1蛋白表达缺失与神经元发育异常的相关性，为疾病机制提供实验依据。
2. **文献名称**：*The Role of ELP1 in mRNA Translation: Insights from CRISPR/Cas9 Knockout and Antibody-Based Detection*
**作者**：Chen L, et al.
**摘要**：通过CRISPR/Cas9敲除ELP1基因并结合特异性抗体验证，证明ELP1通过调控tRNA修饰影响mRNA翻译效率，其抗体在HeLa细胞中表现出高特异性。
3. **文献名称**：*Development of a Novel Monoclonal Antibody Targeting ELP1 for Neuroblastoma Diagnosis*
**作者**：Wang Y, et al.
**摘要**：开发了一种高灵敏度的ELP1单克隆抗体，用于神经母细胞瘤组织样本的免疫组化检测，证实ELP1低表达与肿瘤转移风险显著相关，为临床诊断提供新工具。
注：以上内容为示例，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。
The ELP1 antibody targets the ELP1 (Elongator Complex Protein 1) protein, a critical subunit of the Elongator complex, which plays diverse roles in transcriptional regulation, tRNA modification, and cytoskeletal dynamics. ELP1. also known as IKAP or IKBKAP, is involved in histone acetylation, facilitating RNA polymerase II-mediated transcription elongation, and ensuring proper tRNA wobble uridine modification, crucial for translational fidelity. Mutations in the ELP1 gene are linked to familial dysautonomia (FD), a rare hereditary neurodegenerative disorder characterized by autonomic and sensory dysfunction. In FD, a splicing defect reduces functional ELP1 levels, disrupting neuronal development and survival.
ELP1 antibodies are essential tools for studying ELP1 expression, localization, and interactions in both physiological and pathological contexts. They are widely used in Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ELP1's role in neurodevelopment, cancer (e.g., its tumor-suppressive effects in neuroblastoma), and neurodegeneration. Additionally, these antibodies aid in diagnosing FD and evaluating therapeutic strategies aimed at restoring ELP1 function. Commercial ELP1 antibodies are typically polyclonal or monoclonal, validated for specificity across human and model organisms. Their application extends to elucidating molecular mechanisms underlying Elongator dysfunction in diseases and exploring potential biomarkers or therapeutic targets.
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