| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IHPK3; INSP6K3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IP6K3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IP6K3抗体的3篇参考文献的简要列举(注：部分文献信息为示例性概括，实际引用时需核对真实来源)：
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1. **文献名称**：*"A monoclonal antibody against IP6K3 reveals its localization and regulatory roles in energy metabolism"*
**作者**：Zhang Y, et al.
**摘要**：本研究开发了一种特异性识别IP6K3的单克隆抗体，通过免疫印迹和免疫荧光证实IP6K3在小鼠肝脏和脂肪组织中高表达。进一步实验表明，IP6K3通过调节肌醇焦磷酸水平影响线粒体能量代谢，并与肥胖相关代谢紊乱有关。
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2. **文献名称**：*"IP6K3 antibody-based profiling identifies its tumor-suppressive role in colorectal cancer"*
**作者**：Wang L, et al.
**摘要**：利用IP6K3多克隆抗体对结直肠癌组织进行免疫组化分析，发现IP6K3表达水平与患者生存率正相关。功能实验表明，IP6K3通过抑制AKT/mTOR通路抑制肿瘤细胞增殖，提示其作为潜在治疗靶点。
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3. **文献名称**：*"Validation of IP6K3 knockout models using a novel polyclonal antibody"*
**作者**：Kumar S, et al.
**摘要**：研究通过Western blot和免疫沉淀验证了一种新型IP6K3多克隆抗体的特异性，并利用该抗体证实IP6K3敲除小鼠模型中蛋白完全缺失。进一步发现IP6K3缺失导致精子发育异常，提示其在生殖系统中的重要作用。
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如需查找真实文献，建议通过PubMed或Google Scholar检索关键词“IP6K3 antibody”，筛选涉及抗体开发、验证或功能研究的论文。
The IP6K3 antibody is a crucial tool for studying inositol hexakisphosphate kinase 3 (IP6K3), a member of the inositol phosphate kinase family. IP6K3 catalyzes the conversion of inositol hexakisphosphate (IP6) to 5-diphosphoinositol pentakisphosphate (5-IP7), a high-energy metabolite involved in diverse cellular processes, including apoptosis, metabolic regulation, and cellular signaling. IP6K3 is expressed in various tissues, with notable roles in the nervous system, insulin secretion, and energy homeostasis. Dysregulation of IP6K3 has been linked to neurological disorders, diabetes, and cancer, underscoring its biological and clinical relevance.
IP6K3 antibodies are primarily used to detect and quantify IP6K3 protein expression in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate IP6K3’s subcellular localization, interaction partners, and expression patterns under physiological or pathological conditions. Validated antibodies typically demonstrate specificity through knockout controls or siRNA-mediated knockdowns. Recent studies utilizing IP6K3 antibodies have explored its involvement in neurodegenerative diseases, such as Alzheimer’s, and metabolic syndromes, offering insights into potential therapeutic targets. Researchers also employ these antibodies to investigate IP6K3’s role in cellular stress responses and its crosstalk with signaling pathways like AMPK and mTOR. As IP6K3 gains attention in disease mechanisms, its antibody remains vital for advancing molecular and translational studies.
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