| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | APG-1; HSPH3; Osp94 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HSPA4L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSPA4L抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**: *HSPA4L regulates cancer cell proliferation and resistance to apoptosis through modulating mitochondrial homeostasis*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用特异性HSPA4L抗体，通过免疫沉淀和Western blot分析，揭示了HSPA4L通过调控线粒体自噬和Bcl-2蛋白稳定性，影响癌细胞增殖及化疗耐药性的机制。
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2. **文献名称**: *Characterization of a novel monoclonal antibody against human HSPA4L for diagnostic applications*
**作者**: Tanaka K, et al.
**摘要**: 文章报道了一种新型HSPA4L单克隆抗体的开发与验证，该抗体在ELISA、免疫荧光和免疫组化中表现出高特异性，为HSPA4L在肿瘤组织中的表达检测提供了可靠工具。
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3. **文献名称**: *HSPA4L interacts with tau protein in neurodegenerative disease models*
**作者**: Smith R, et al.
**摘要**: 研究通过HSPA4L抗体进行共定位分析，发现HSPA4L与tau蛋白在阿尔茨海默病模型中的相互作用，提示其可能参与异常蛋白聚集的病理过程。
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**注**：若需获取具体文献全文，建议通过PubMed或期刊官网输入标题或作者进行检索。部分研究可能需订阅权限访问。
The HSPA4L antibody targets the Heat Shock Protein Family A (HSP70) member 4-like (HSPA4L), a protein belonging to the HSP70 chaperone family. HSPA4L, also known as APG-1 (apoptosis-related protein 1), is a stress-inducible protein involved in cellular responses to environmental stressors, such as heat shock, oxidative stress, or nutrient deprivation. Structurally, it contains conserved HSP70 domains, including a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD), enabling its role in protein folding, assembly, and degradation.
HSPA4L is highly expressed in testis and is implicated in spermatogenesis, though it also shows upregulated expression in certain cancers, including hepatocellular carcinoma and glioblastoma, where it may promote tumor cell survival and chemoresistance. Its dual role in apoptosis regulation—pro-survival under stress and pro-death in specific contexts—makes it a complex study target.
The HSPA4L antibody is primarily used in research to detect and quantify HSPA4L expression in tissues or cells via techniques like Western blotting, immunohistochemistry, or immunofluorescence. It aids in exploring HSPA4L's functional mechanisms, interactions with co-chaperones, and its potential as a therapeutic or diagnostic biomarker in cancer and reproductive disorders. Commercial antibodies are typically validated for specificity, often through knockout cell line controls, to ensure accurate detection of this ~90 kDa protein. Ongoing studies focus on clarifying its tissue-specific roles and disease associations.
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