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Rabbit Polyclonal GUCY1B2 Antibody

  • 中文名： GUCY1B2抗体
  • 别    名： GC-SB2
货号: IPDX13545
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesGC-SB2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human GUCY1B2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于GUCY1B2抗体的示例性参考文献(注：以下内容为模拟生成，非真实文献，仅供参考)：

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1. **文献名称**：*GUCY1B2 Expression in Colorectal Cancer: Prognostic Implications and Antibody Validation*

**作者**：Smith A, et al. (2018)

**摘要**：本研究通过免疫组化及Western blot验证了一种新型GUCY1B2单克隆抗体的特异性，发现GUCY1B2在结直肠癌组织中高表达，且与患者生存率降低显著相关，提示其作为潜在生物标志物的价值。

2. **文献名称**：*Role of GUCY1B2 in Vascular Smooth Muscle Cells: Insights from Antibody-Based Knockdown Studies*

**作者**：Johnson R, et al. (2020)

**摘要**：利用特异性抗体抑制GUCY1B2蛋白表达，发现其下调导致血管平滑肌细胞cGMP信号通路受损，可能参与动脉粥样硬化的病理机制，为心血管疾病治疗提供新靶点。

3. **文献名称**：*Development of a High-Affinity Monoclonal Antibody Against Human GUCY1B2 for Diagnostic Applications*

**作者**：Chen L, et al. (2019)

**摘要**：报道了一种高亲和力GUCY1B2单克隆抗体的开发过程，通过ELISA和免疫荧光验证其灵敏度及特异性，成功应用于临床样本的蛋白定量检测。

4. **文献名称**：*GUCY1B2 in Neurological Disorders: A Review of Antibody-Based Research Advances*

**作者**：Brown K, et al. (2021)

**摘要**：综述了GUCY1B2在神经退行性疾病中的潜在作用，总结现有抗体工具在脑组织定位及功能研究中的应用，并探讨未来研究方向。

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建议通过 **PubMed**、**Google Scholar** 或 **Web of Science** 检索关键词“GUCY1B2 antibody”获取最新真实文献。

背景信息

The GUCY1B2 antibody is designed to target the guanylate cyclase 1 soluble subunit beta 2 (GUCY1B2), a component of the soluble guanylate cyclase (sGC) enzyme complex. sGC plays a critical role in the nitric oxide (NO) signaling pathway by catalyzing the conversion of GTP to cyclic guanosine monophosphate (cGMP), a secondary messenger involved in vasodilation, neurotransmission, and cellular homeostasis. GUCY1B2 pairs with an alpha subunit (e.g., GUCY1A1 or GUCY1A2) to form functional heterodimers, which are activated by NO binding to their heme moiety. Dysregulation of sGC activity has been implicated in cardiovascular diseases, pulmonary hypertension, and neurodegenerative disorders. The GUCY1B2 antibody is utilized in research to study protein expression, localization, and functional interactions in tissues or cell models, particularly in contexts exploring NO-cGMP pathway disruptions. Its applications include techniques like Western blotting, immunohistochemistry, and immunofluorescence. Understanding GUCY1B2's role may aid in developing therapeutics targeting sGC for conditions like hypertension or heart failure. Specificity and validation of the antibody are critical, as cross-reactivity with other sGC subunits can complicate interpretations.

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