| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GST4; GSTM; GTHMUS; GSTM2-2 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GSTM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GSTM2抗体的3篇参考文献示例(注：以下信息为模拟虚构，仅供参考实际文献需通过学术数据库查询)：
1. **标题**: "GSTM2 Expression in Human Liver: Role of Antibody-Based Detection in Metabolic Disease"
**作者**: Smith A, et al.
**摘要**: 研究通过特异性GSTM2抗体分析人肝组织中GSTM2蛋白表达水平，揭示其在代谢性疾病(如非酒精性脂肪肝)中的表达下调，提示GSTM2可能参与氧化应激调控。
2. **标题**: "Development of a Monoclonal Antibody for GSTM2 and Its Application in Cancer Prognosis"
**作者**: Zhang L, et al.
**摘要**: 报道一种高特异性抗GSTM2单克隆抗体的开发，并用于检测结直肠癌组织中GSTM2的亚细胞定位。结果表明，GSTM2低表达与患者较差生存率相关。
3. **标题**: "GSTM2 Isoform-Specific Antibody Reveals Differential Roles in Cellular Detoxification"
**作者**: Tanaka K, et al.
**摘要**: 利用GSTM2同工酶特异性抗体，比较不同组织(如肺、肾)中GSTM2的分布及功能差异，证实其在致癌物代谢中的组织特异性保护作用。
如需真实文献，建议通过 **PubMed** 或 **Google Scholar** 检索关键词“GSTM2 antibody”、“GSTM2 protein expression”等，并筛选近年研究。
The glutathione S-transferase Mu 2 (GSTM2) antibody is a tool used to detect and study the GSTM2 protein, a member of the glutathione S-transferase (GST) enzyme family. GSTM2 belongs to the Mu class of GSTs, which play critical roles in cellular detoxification by catalyzing the conjugation of glutathione to electrophilic substrates, including carcinogens, toxins, and oxidative stress byproducts. This enzyme is predominantly expressed in the liver, kidneys, and testes, contributing to phase II metabolism and protection against oxidative damage. Dysregulation of GSTM2 has been implicated in various diseases, including cancer, neurodegenerative disorders, and drug resistance, making it a target for therapeutic and diagnostic research.
The GSTM2 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression levels, localization, and tissue distribution. Researchers utilize it to investigate GSTM2's role in cellular defense mechanisms, metabolic pathways, and disease progression. Specificity and validation are crucial, as cross-reactivity with other GST isoforms (e.g., GSTM1) must be ruled out. Studies leveraging this antibody have revealed associations between GSTM2 polymorphisms and disease susceptibility, as well as its potential as a biomarker for oxidative stress-related conditions. Its applications span basic research, clinical diagnostics, and drug development, underscoring its importance in understanding redox biology and precision medicine.
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