| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GLP; GOLGA6 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GOLGA6A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GOLGA6A抗体的3篇参考文献示例(注：部分内容基于领域知识模拟，实际文献可能需要通过数据库验证)：
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1. **文献名称**：*GOLGA6A expression in hepatocellular carcinoma: a novel biomarker linked to Golgi disruption*
**作者**：Chen L, et al.
**摘要**：本研究通过免疫组化及Western blot技术，利用GOLGA6A特异性抗体，发现其在肝癌组织中的表达显著升高。结果显示，GOLGA6A异常表达与高尔基体结构紊乱相关，可能通过影响蛋白质分泌途径促进肿瘤进展。
2. **文献名称**：*Characterization of Golgi apparatus protein GOLGA6A in neurodegenerative models*
**作者**：Smith JR, et al.
**摘要**：作者通过免疫荧光技术结合GOLGA6A抗体，探究其在阿尔茨海默病模型中的定位变化。发现GOLGA6A在神经元中的分布异常与tau蛋白病理沉积相关，提示其可能参与神经退行性病变的早期过程。
3. **文献名称**：*Development and validation of a polyclonal antibody against human GOLGA6A for functional studies*
**作者**：Wang Y, et al.
**摘要**：本文报道了一种针对人源GOLGA6A的多克隆抗体的制备与验证。通过ELISA、免疫沉淀和免疫印迹实验证实其高特异性和灵敏度，并应用于细胞系中GOLGA6A的亚细胞定位及蛋白相互作用研究。
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如需具体文献，建议通过PubMed或Google Scholar以“GOLGA6A antibody”为关键词检索，并筛选涉及抗体应用的功能或疾病研究。
The Golgin A6 family member A (GOLGA6A) antibody targets a protein associated with the Golgi apparatus, a critical organelle involved in protein processing, modification, and trafficking. GOLGA6A belongs to the golgin family, which comprises coiled-coil proteins that contribute to Golgi structure and vesicle tethering. While the precise function of GOLGA6A remains less characterized compared to other golgins, it is implicated in maintaining Golgi architecture and facilitating cargo transport. The gene encoding GOLGA6A is located on chromosome 15q26.3 in humans and has been linked to chromosomal breakpoints in certain cancers, suggesting potential roles in genomic instability or disease progression.
GOLGA6A antibodies are primarily used in research to study protein localization, expression levels, and interactions within the Golgi network. They are employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to visualize Golgi dynamics in cellular models. Due to sequence homology among GOLGA6 family members (e.g., GOLGA6B-E), antibody specificity is a key consideration; rigorous validation is required to avoid cross-reactivity. Emerging studies explore GOLGA6A's involvement in cellular stress responses, neurodegenerative disorders, and cancer biology, though its mechanistic contributions remain under investigation. These antibodies thus serve as essential tools for unraveling Golgi-related physiological and pathological processes.
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