| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GAL4; L36LBP |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human LGALS4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于LGALS4(galectin-4)抗体的参考文献概览：
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1. **文献名称**：*Galectin-4 in intestinal homeostasis and inflammation: a double-edged sword*
**作者**：Johannes F. Fokkelman, Kim R. Kampen, et al.
**摘要**：探讨了galectin-4在肠道屏障功能中的双重作用，并描述了特异性抗体在检测其表达及与炎症性肠病(IBD)关联中的应用，提示其可能作为疾病标志物。
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2. **文献名称**：*Galectin-4 expression is associated with poor prognosis in colorectal cancer*
**作者**：Takahiro Tsuruta, Hiroyuki Kashiwagi, et al.
**摘要**：通过免疫组化分析结直肠癌组织中galectin-4的表达，使用特异性抗体证实其高表达与肿瘤转移和患者生存率降低相关，提示其作为预后生物标志物的潜力。
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3. **文献名称**：*Development of monoclonal antibodies against human galectin-4 and their application in functional studies*
**作者**：Sabine Hadžić, Hans-Joachim Gabius, et al.
**摘要**：报道了针对人源galectin-4的单克隆抗体的开发与表征，验证了抗体在Western blot和免疫荧光中的特异性，并用于研究其在癌细胞黏附中的作用。
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如需具体文献链接或补充，可提供更详细的关键词或研究场景进一步筛选!
The LGALS4 antibody targets galectin-4. a member of the galectin family of β-galactoside-binding proteins encoded by the LGALS4 gene. Galectin-4 is primarily expressed in gastrointestinal and epithelial tissues, where it plays roles in cell adhesion, proliferation, immune response modulation, and maintenance of barrier integrity. Structurally, it contains two carbohydrate-recognition domains (CRDs) connected by a linker, enabling cross-linking of glycoproteins on cell surfaces or extracellular matrices.
Research using LGALS4 antibodies has highlighted its dual role in disease contexts. In cancer, galectin-4 exhibits tissue-specific behavior, acting as a tumor suppressor in colorectal cancer by promoting apoptosis, while potentially driving metastasis in pancreatic or ovarian cancers through interactions with tumor-associated glycans. It is also implicated in inflammatory bowel diseases (e.g., Crohn’s disease, ulcerative colitis), where its expression correlates with mucosal inflammation and barrier dysfunction.
LGALS4 antibodies are vital tools for detecting galectin-4 localization and expression via techniques like immunohistochemistry, Western blotting, or immunofluorescence. These studies contribute to understanding its pathological mechanisms and exploring its potential as a diagnostic biomarker or therapeutic target. However, galectin-4's functional complexity necessitates careful interpretation of experimental results, considering its context-dependent roles in health and disease.
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