| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GAT3; GAT4; GAT-3 |
| WB Predicted band size | 71 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC6A11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC6A11抗体的参考文献示例(内容为模拟概括，非真实文献)：
1. **"Characterization of a polyclonal antibody against SLC6A11 (GAT-3) for neuroanatomical mapping"**
- **作者**: Smith A, et al.
- **摘要**: 开发并验证了一种针对SLC6A11的多克隆抗体，通过免疫组化和Western blot证实其在啮齿类动物脑组织中的特异性，揭示了SLC6A11在星形胶质细胞中的广泛分布，提示其在GABA能信号调控中的作用。
2. **"SLC6A11 expression dynamics in epileptic mouse models revealed by antibody-based detection"**
- **作者**: Chen L, et al.
- **摘要**: 使用SLC6A11抗体分析癫痫模型中蛋白表达变化，发现海马区SLC6A11表达显著下调，可能与突触GABA浓度异常及神经元过度兴奋相关。
3. **"Antibody validation for SLC6A11 in human postmortem brain tissues"**
- **作者**: Johnson R, et al.
- **摘要**: 通过免疫荧光和蛋白质印迹验证商用SLC6A11抗体在人脑组织中的特异性，发现其在皮层及基底节的高表达，为神经精神疾病研究提供可靠工具。
4. **"SLC6A11-mediated GABA transport in glioma progression: Insights from antibody-targeted analysis"**
- **作者**: Wang Y, et al.
- **摘要**: 利用SLC6A11抗体研究胶质瘤组织，发现其表达水平与肿瘤侵袭性呈负相关，提示SLC6A11可能通过调节微环境GABA影响癌细胞增殖。
(注：以上为示例，实际文献需通过PubMed/Google Scholar以关键词“SLC6A11 antibody”检索。)
The solute carrier family 6 member 11 (SLC6A11) gene encodes the GABA transporter 3 (GAT-3), a transmembrane protein responsible for the reuptake of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. As part of the SLC6 family of sodium- and chloride-dependent transporters, GAT-3 regulates extracellular GABA levels, maintaining synaptic transmission balance and preventing excessive neuronal excitation. Dysregulation of GAT-3 has been implicated in neurological disorders, including epilepsy, anxiety, and sleep disturbances, making it a target for therapeutic research.
SLC6A11 antibodies are essential tools for studying the expression, localization, and function of GAT-3 in biological systems. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize protein distribution in brain tissues, particularly in astrocytes and specific neuronal populations. High-quality SLC6A11 antibodies exhibit specificity for epitopes in the C-terminal or extracellular domains of GAT-3. often validated through knockout controls or siRNA knockdown experiments. Researchers utilize these antibodies to explore GABAergic signaling alterations in disease models, drug response studies, and comparative analyses across species. Commercial SLC6A11 antibodies are typically raised in rabbits or mice, with validation data provided for target applications. Their reliability supports ongoing investigations into neuropharmacology and pathophysiology linked to GABA transport mechanisms.
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