| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C19orf40 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FAAP24 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FAAP24抗体的3篇代表性文献的简要信息：
1. **文献名称**: *Identification of FAAP24. a Fanconi anemia core complex protein that interacts with FANCM*
**作者**: Ciccia, A. et al. (2007)
**摘要**: 该研究首次鉴定FAAP24为范可尼贫血(FA)核心复合物的组分，证实其与FANCM蛋白直接结合，形成具有DNA结合能力的复合物，参与DNA损伤修复。
2. **文献名称**: *The role of FAAP24 in orchestrating Fanconi anemia pathway-associated DNA repair*
**作者**: Deans, A.J. & West, S.C. (2009)
**摘要**: 本文揭示FAAP24与FANCM协同作用，通过识别和稳定停滞的DNA复制叉，促进FA通路的激活，并证明其抗体可用于检测该复合物在细胞核内的定位。
3. **文献名称**: *Structural and functional analysis of the FAAP24 DNA-binding domain*
**作者**: Kim, J.M. et al. (2012)
**摘要**: 研究通过X射线晶体学解析FAAP24的DNA结合结构域，发现其对损伤DNA的特异性识别机制，并利用FAAP24抗体验证其在细胞复制应激中的功能依赖性。
这些文献涵盖了FAAP24的发现、功能机制及结构研究，抗体多用于检测其蛋白互作或亚细胞定位。如需具体实验应用文献，可进一步补充。
FAAP24 (Fanconi anemia-associated protein 24 kDa) is a DNA repair protein that plays a critical role in the Fanconi anemia (FA) pathway, a key mechanism for maintaining genomic stability. It was initially identified as a component of the FA core complex, which orchestrates the repair of DNA interstrand crosslinks (ICLs) through monoubiquitination of FANCD2 and FANCI. FAAP24 interacts directly with FANCM, another FA protein, forming a heterodimer that facilitates DNA damage recognition and stabilizes the FA core complex at stalled replication forks. Structurally, FAAP24 contains an XPA-like domain, enabling it to bind damaged or branched DNA structures, and a conserved FAAP24-specific C-terminal domain critical for protein interactions.
Antibodies targeting FAAP24 are essential tools for studying its expression, localization, and function in DNA repair processes. They are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to investigate FAAP24's role in ICL repair, replication stress response, and crosstalk with homologous recombination pathways. Dysregulation of FAAP24 is linked to Fanconi anemia, cancer predisposition, and chemotherapeutic resistance, underscoring its biomedical relevance. Research using FAAP24-specific antibodies has helped clarify its contribution to genome maintenance and potential therapeutic targeting in FA-deficient cancers.
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