| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ZNF560 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于ZNF560相关研究的示例性参考文献(注：由于ZNF560抗体相关文献较少，以下为假设性示例，建议通过PubMed或Google Scholar查询最新文献)：
1. **文献名称**: "ZNF560 Antibody Characterization in Epigenetic Regulation"
**作者**: Li X, et al.
**摘要**: 报道了一种新型ZNF560抗体的开发与验证，证明其在染色质免疫沉淀(ChIP)中的应用，揭示ZNF560通过结合特定DNA序列调控表观遗传修饰。
2. **文献名称**: "Role of ZNF560 in Cancer: Antibody-Based Detection"
**作者**: Wang Y, et al.
**摘要**: 使用ZNF560特异性抗体分析其在结直肠癌中的表达模式，发现其表达下调与患者预后不良相关，提示其可能的肿瘤抑制功能。
3. **文献名称**: "ZNF560 Antibody Validation for Immunohistochemistry"
**作者**: Zhang R, et al.
**摘要**: 验证了商业ZNF560抗体在小鼠和人类组织中的特异性，确认其在免疫组化(IHC)和Western blot中的可靠性，并发现其在神经组织中高表达。
4. **文献名称**: "ZNF560 Interaction Networks Revealed by IP-MS"
**作者**: Chen H, et al.
**摘要**: 利用ZNF560抗体进行免疫沉淀-质谱联用(IP-MS)，鉴定出与ZNF560相互作用的多个转录因子，提示其在基因转录调控中的枢纽作用。
**注意**：以上为模拟文献，实际研究需通过学术数据库检索。建议使用关键词“ZNF560 antibody”或“ZNF560 function”在PubMed、Web of Science等平台查询最新成果。ZNF560作为锌指蛋白家族成员，可能参与基因转录调控，但具体机制仍需更多研究。
The ZNF560 antibody is a research tool designed to target the zinc finger protein 560 (ZNF560), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. These proteins are characterized by tandem C2H2-type zinc finger motifs, which facilitate sequence-specific DNA binding, and a KRAB domain that often mediates transcriptional repression by recruiting chromatin-modifying complexes. ZNF560 is hypothesized to play roles in gene regulation, particularly in developmental processes, cell differentiation, or stress responses, though its precise biological functions remain under investigation.
The antibody is typically produced in hosts such as rabbits or mice using immunogenic peptides or recombinant protein fragments corresponding to specific epitopes of ZNF560. It is widely utilized in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect ZNF560 expression levels, localization, and interactions in cellular or tissue samples. Validation often includes checks for specificity via knockdown/knockout controls or cross-reactivity assessments.
Studies involving ZNF560 antibodies aim to clarify its involvement in diseases such as cancer, neurological disorders, or autoimmune conditions, where aberrant zinc finger protein activity has been implicated. However, comprehensive mechanistic insights into ZNF560’s pathways are still emerging, highlighting the importance of reliable antibodies for ongoing research. Commercial variants may vary in clonality (monoclonal/polyclonal), conjugates (e.g., HRP, fluorescent tags), and species reactivity, necessitating context-specific selection.
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