| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human EMX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EMX2抗体的3篇参考文献示例(文献信息为模拟概括，仅供参考)：
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1. **文献名称**：*EMX2 regulates epithelial-mesenchymal transition in glioblastoma through Wnt/β-catenin signaling*
**作者**：Smith A, et al. (2020)
**摘要**：研究利用EMX2抗体进行免疫组化及Western blot分析，发现EMX2通过抑制Wnt通路抑制胶质母细胞瘤的侵袭性，其低表达与患者不良预后相关。
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2. **文献名称**：*Developmental expression of EMX2 in the mouse kidney and its role in nephron formation*
**作者**：Tanaka K, et al. (2018)
**摘要**：通过EMX2抗体免疫荧光染色，揭示EMX2在小鼠胚胎肾脏发育中的时空表达模式，证明其缺失导致肾单位结构异常，影响肾小管形成。
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3. **文献名称**：*EMX2 as a tumor suppressor in endometrial cancer: Correlation with hormone receptor pathways*
**作者**：Lee H, et al. (2021)
**摘要**：采用EMX2抗体检测子宫内膜癌组织样本，发现EMX2表达与雌激素受体α负相关，其缺失通过激活PI3K/AKT通路促进肿瘤进展。
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如需具体文献，建议通过PubMed或Web of Science以“EMX2 antibody”及研究领域(如癌症、发育生物学)为关键词检索。
The EMX2 antibody is a tool used to detect the EMX2 (Empty Spiracles Homeobox 2) protein, a transcription factor encoded by the *EMX2* gene, which belongs to the homeobox gene family. EMX2 plays critical roles in embryonic development, particularly in the patterning of the brain, urogenital system, and skeletal structures. During neurodevelopment, it regulates cortical layer formation and regional identity in the forebrain. Dysregulation of EMX2 has been implicated in neurological disorders, congenital malformations, and cancers, where it may act as a tumor suppressor by modulating cell proliferation and differentiation.
The EMX2 antibody is widely employed in research to study protein expression, localization, and function in tissues or cell lines. It is commonly used in techniques such as immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF). Validating the antibody's specificity is essential, often through knockout controls or siRNA-mediated knockdown. Commercial EMX2 antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein's conserved regions. Researchers also utilize this antibody to explore EMX2's interaction with signaling pathways (e.g., Wnt or BMP) and its epigenetic regulation in diseases. Its applications extend to developmental biology, cancer research, and studies of genetic disorders linked to *EMX2* mutations or altered expression.
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