Rabbit Polyclonal CNOT6 Antibody

The CNOT6 antibody is a research tool designed to target the CNOT6 protein, a critical subunit of the CCR4-NOT complex, a conserved multi-protein complex involved in post-transcriptional gene regulation. The CCR4-NOT complex plays diverse roles in mRNA deadenylation, decay, and translational repression, impacting cellular processes such as development, stress responses, and metabolism. CNOT6. also known as CCR4-associated factor 6. functions as a deadenylase enzyme that shortens poly(A) tails of mRNAs, promoting their degradation or silencing. It works in coordination with other subunits like CNOT7/8 to regulate gene expression dynamically. Antibodies against CNOT6 are widely used in molecular biology to study its expression, localization, and interactions within the complex. They enable techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore CNOT6's role in cellular pathways, including its involvement in diseases such as cancer, neurodegenerative disorders, and viral infections. These antibodies are essential for validating protein knockdowns, mapping interaction networks, and understanding how CCR4-NOT-mediated mRNA regulation influences physiological and pathological states. Proper validation of CNOT6 antibodies (e.g., specificity, cross-reactivity checks) is crucial to ensure reliability in experimental models ranging from mammalian cells to invertebrates.