| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | STBP; TH2B; H2BFU; TSH2B; hTSH2B; TSH2B.1; HIST1H2BA; bA317E16.3 |
| WB Predicted band size | 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human H2BC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于H2BC1抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献可能需要通过学术数据库查询确认)：
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1. **文献名称**: *"H2BC1 modulates chromatin accessibility and maintains transcriptional fidelity in human cells"*
**作者**: Li, X., et al.
**摘要**: 本研究探讨了组蛋白变体H2BC1在染色质动态调控中的作用。通过开发特异性H2BC1抗体，作者发现H2BC1通过调节核小体稳定性影响染色质开放区域，其缺失导致DNA损伤修复异常和转录错误。
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2. **文献名称**: *"A novel H2BC1 antibody reveals its overexpression in prostate cancer progression"*
**作者**: Smith, J.R., et al.
**摘要**: 研究利用新开发的H2BC1单克隆抗体，分析了前列腺癌组织中H2BC1的表达模式。结果显示H2BC1在转移性肿瘤中显著高表达，并与患者预后不良相关，提示其作为癌症生物标志物的潜力。
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3. **文献名称**: *"Epigenetic regulation of H2BC1 in embryonic stem cell differentiation"*
**作者**: Wang, Y., et al.
**摘要**: 通过免疫沉淀(ChIP)结合H2BC1抗体，研究发现H2BC1在小鼠胚胎干细胞分化过程中特异性富集于多能性基因启动子区域，调控组蛋白修饰(如H3K4me3)并影响细胞命运决定。
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如需具体文献，建议通过 **PubMed** 或 **Google Scholar** 搜索关键词“H2BC1 antibody”或“H2BC1 histone”获取最新研究。
The H2BC1 antibody targets histone H2B type 1-C (H2BC1), a core component of nucleosomes involved in chromatin organization and epigenetic regulation. Histone H2B is one of the five major histone families (H1. H2A, H2B, H3. H4) that compact DNA into chromatin, playing critical roles in DNA packaging, transcription, replication, and repair. H2BC1. encoded by the *HIST1H2BC* gene, is a replication-dependent histone variant expressed during the S phase of the cell cycle. As part of the H2B family, it contributes to nucleosome stability and interacts with other histones to regulate chromatin accessibility.
H2BC1-specific antibodies are essential tools for studying histone modifications, chromatin dynamics, and gene expression patterns. They are widely used in techniques like chromatin immunoprecipitation (ChIP), immunofluorescence (IF), and Western blotting to investigate H2BC1's localization, post-translational modifications (e.g., phosphorylation, ubiquitination), and roles in cellular processes such as apoptosis or DNA damage response. Dysregulation of H2B variants, including H2BC1. has been implicated in cancer, developmental disorders, and epigenetic diseases, making these antibodies valuable for both basic research and clinical applications. Commercial H2BC1 antibodies are typically raised in rabbits or mice, with validation across multiple applications to ensure specificity and reproducibility.
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