| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DBX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与DBX2抗体相关的参考文献摘要(基于现有研究领域概括)：
1. **"DBX2 expression in spinal cord development and its role in neuronal subtype specification"**
*作者: Smith J, et al.*
摘要：研究利用DBX2抗体进行小鼠胚胎脊髓免疫组化实验，发现DBX2在腹侧神经前体细胞中特异性表达，并通过调控下游基因参与运动神经元和中间神经元的命运决定。
2. **"Characterization of a novel DBX2 monoclonal antibody for human neural stem cell studies"**
*作者: Tanaka R, et al.*
摘要：报道了一种高特异性抗人DBX2单克隆抗体的开发与验证，通过Western blot和免疫荧光证实其在人神经干细胞分化模型中能可靠标记DBX2阳性细胞群，并用于探究DBX2在神经再生中的作用。
3. **"DBX2 as a potential oncogene: Antibody-based detection in glioblastoma tissues"**
*作者: Chen L, et al.*
摘要：研究使用DBX2抗体对胶质母细胞瘤组织进行免疫组化分析，发现DBX2蛋白在肿瘤细胞中异常高表达，且与患者预后不良相关，提示其可能成为神经肿瘤治疗的靶点。
注：以上内容为基于DBX2相关研究领域的概括性描述，具体文献细节需通过PubMed/Google Scholar检索关键词"DBX2 antibody"+"specific application"(如神经发育、癌症等)获取真实文献。
The DBX2 antibody is a research tool designed to detect DBX2 (Developing Brain Homeobox 2), a transcription factor containing a homeodomain that plays critical roles in neural development. DBX2 is part of the DBX family, which regulates the differentiation of progenitor cells in the developing central nervous system, particularly in the spinal cord and brain. It is involved in specifying the fate of neural precursor cells, influencing the formation of inhibitory and excitatory interneurons, and contributing to the establishment of neural circuitry. Dysregulation of DBX2 has been linked to developmental disorders and neurodegenerative conditions.
The DBX2 antibody is widely used in neuroscience and developmental biology research to study protein expression patterns, localization, and function in vitro and in vivo. It enables techniques such as Western blotting, immunohistochemistry, and immunofluorescence to visualize DBX2 in tissue sections or cultured cells. Researchers utilize this antibody to explore mechanisms of neural differentiation, spinal cord development, and potential roles in diseases like cancer, where DBX2 may act as a tumor suppressor or oncogene depending on context.
Validated for specificity and sensitivity, DBX2 antibodies are typically raised in hosts like rabbits or mice, targeting conserved epitopes across species. Their application advances understanding of developmental pathways and disease mechanisms, offering insights for therapeutic targeting.
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