| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IL-7 |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IL7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇与COX6C抗体相关的文献示例(内容基于公开文献概括，非真实引用，仅供参考)：
1. **文献名称**: "Mitochondrial COX6C expression in prostate cancer: a novel biomarker for oxidative stress"
**作者**: Schmidt TR, et al.
**摘要**: 研究通过COX6C抗体检测前列腺癌组织中线粒体COX6C蛋白的表达水平，发现其表达下调与肿瘤氧化应激增强及不良预后相关。
2. **文献名称**: "Antibody-based profiling of COX6C mutations in mitochondrial encephalomyopathy"
**作者**: Li Y, et al.
**摘要**: 利用COX6C特异性抗体对线粒体脑肌病患者的细胞样本进行蛋白定位分析，揭示了COX6C基因突变导致亚细胞定位异常及呼吸链功能缺陷。
3. **文献名称**: "COX6C knockdown impairs leukemia cell proliferation via ROS-mediated apoptosis"
**作者**: Zhang X, et al.
**摘要**: 通过COX6C抗体验证基因沉默效果，证实抑制COX6C表达可增加白血病细胞内活性氧(ROS)水平并诱导凋亡，提示其作为治疗靶点的潜力。
4. **文献名称**: "Characterization of a monoclonal antibody against human COX6C for mitochondrial complex IV assembly studies"
**作者**: Johnson RB, et al.
**摘要**: 报道了一种高特异性COX6C单克隆抗体的开发，并用于研究线粒体复合体IV的组装机制，证明COX6C在复合体稳定性中的关键作用。
(注：以上为模拟内容，实际文献需通过PubMed/Google Scholar等平台检索确认。)
The cytochrome c oxidase subunit 6C (COX6C) is a nuclear-encoded component of Complex IV in the mitochondrial electron transport chain (ETC), which plays a critical role in cellular energy production via oxidative phosphorylation. COX6C, encoded by the *COX6C* gene in humans, is one of several subunits that assemble with catalytic core proteins to form the functional enzyme responsible for transferring electrons to oxygen, the terminal step in the ETC. This subunit is part of the peripheral region of Complex IV and contributes to its structural stability and regulatory functions.
COX6C-specific antibodies are essential tools for studying mitochondrial biology, particularly in assessing protein expression, localization, and complex assembly in diseases linked to mitochondrial dysfunction. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate conditions such as cancer, neurodegenerative disorders, and metabolic syndromes. For example, altered COX6C expression has been observed in certain cancers, suggesting its potential role as a biomarker or therapeutic target.
Antibodies targeting COX6C are typically validated for specificity using knockout controls or siRNA-mediated knockdown to ensure minimal cross-reactivity with other COX subunits. Commercial COX6C antibodies are often generated in hosts like rabbits or mice, with applications across human, mouse, and rat models. Their utility extends to both basic research exploring mitochondrial dynamics and clinical studies aiming to unravel disease mechanisms tied to energy metabolism defects.
×
