Rabbit Polyclonal BMP10 Antibody

The BMP10 antibody is a crucial tool in studying bone morphogenetic protein 10 (BMP10), a member of the TGF-β superfamily involved in embryonic development and tissue homeostasis. BMP10 plays a vital role in cardiovascular development, particularly in regulating cardiac chamber formation, myocardial wall thickening, and ventricular trabeculation during embryogenesis. It is predominantly expressed in the developing heart and persists postnatally in atrial cardiomyocytes. Dysregulation of BMP10 has been linked to congenital heart defects, heart failure, and pulmonary arterial hypertension. Researchers use BMP10 antibodies to detect and quantify BMP10 expression in tissues or cell cultures, aiding in investigations of heart development, disease mechanisms, and potential therapeutic targets. These antibodies are essential in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Additionally, BMP10 antibodies have therapeutic implications, as BMP10 signaling pathways (e.g., SMAD1/5/8 activation via ALK1/ACVR1 receptors) are explored for modulating cardiac repair and regeneration. Their specificity varies depending on the epitope targeted, with polyclonal antibodies offering broader detection and monoclonal antibodies providing higher precision. Recent studies also highlight BMP10's role in metabolic disorders and cancer, expanding the antibody's research applications beyond cardiovascular biology.