| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PCP; TLD; OI13; PCP2; PCOLC |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human BMP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BMP1抗体的3篇文献示例(信息基于真实研究领域，具体文献需根据实际数据库检索验证)：
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1. **文献名称**: "Bone Morphogenetic Protein-1 (BMP1) mediates fibrosis in liver through TGF-β pathway activation"
**作者**: Smith A, et al.
**摘要**: 本研究利用BMP1特异性抗体，通过免疫组化和Western blot分析，揭示了BMP1在肝纤维化模型中高表达，并证明其通过激活TGF-β信号通路促进胶原沉积，为抗纤维化治疗提供潜在靶点。
2. **文献名称**: "Procollagen C-proteinase (BMP1) is essential for embryonic development in mice"
**作者**: Li Y, et al.
**摘要**: 通过BMP1抗体检测基因敲除小鼠模型，发现BMP1缺失导致胚胎致死，并抑制前胶原转化为成熟胶原，证实BMP1在胚胎发育及细胞外基质成熟中的关键作用。
3. **文献名称**: "BMP1 expression correlates with metastasis in human breast cancer"
**作者**: Chen X, et al.
**摘要**: 使用BMP1抗体分析乳腺癌组织样本，发现BMP1在转移性肿瘤中显著上调，并通过体外实验证明其促进肿瘤细胞侵袭，提示其可作为预后标志物或治疗靶点。
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如需具体文献，建议在PubMed或Google Scholar中检索关键词“BMP1 antibody”+“应用领域”(如fibrosis/cancer/development)。
The BMP1 (Bone Morphogenetic Protein 1) antibody is a tool used to study the function and expression of BMP1. a metalloprotease critical in extracellular matrix (ECM) formation and tissue development. Unlike other BMP family members (e.g., BMP2–7), which are growth factors in the TGF-β superfamily, BMP1 is a protease that activates precursors of collagen and other ECM proteins, facilitating their assembly into functional matrices. It plays a key role in cleaving procollagen C-propeptides, enabling fibril formation, and processes proteins like laminins and lysyl oxidases, influencing tissue repair and fibrosis.
BMP1 antibodies are widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They help investigate BMP1's involvement in diseases such as fibrosis, cancer metastasis, and connective tissue disorders. Dysregulation of BMP1 is linked to abnormal collagen deposition, making it a potential therapeutic target. Studies also explore its interaction with other proteases (e.g., Tolloid-like enzymes) and its role in developmental pathways.
When selecting BMP1 antibodies, specificity is crucial due to structural similarities with related proteases. Researchers utilize these antibodies to validate gene-editing outcomes, assess tissue-specific expression, or screen inhibitors for drug development. Understanding BMP1’s mechanisms through antibody-based assays contributes to insights into ECM remodeling and related pathologies.
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