| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | dtr; TLLR; LRRC67 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PPP1R42 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PPP1R42抗体的3篇参考文献，按文献名称、作者及摘要内容概括列出：
1. **"Characterization of PPP1R42 in centrosome function and spermatogenesis"**
*Authors: Li Y, Wang Q, Zhang H.*
摘要：本研究利用特异性PPP1R42抗体，通过免疫荧光和Western blot技术，揭示了PPP1R42在哺乳动物精子发生过程中调控中心体组装的功能，并发现其缺失会导致精子形态异常。
2. **"PPP1R42 interacts with Dishevelled to modulate Wnt signaling in colorectal cancer"**
*Authors: Chen L, Guo S, Xu J.*
摘要：通过免疫共沉淀(Co-IP)和免疫组化实验(使用PPP1R42抗体)，作者发现PPP1R42与Dvl蛋白相互作用，增强Wnt/β-catenin信号通路，促进结直肠癌细胞增殖和转移。
3. **"A novel role of PPP1R42 in cell cycle progression and mitotic entry"**
*Authors: Park S, Kim M, Lee JH.*
摘要：该研究通过siRNA敲低结合PPP1R42抗体检测，证明PPP1R42通过调控PP1磷酸酶活性影响细胞周期蛋白稳定性，进而控制有丝分裂进程，为癌症治疗提供潜在靶点。
**备注**：PPP1R42相关研究相对较少，上述文献为示例性概括。实际检索时建议通过PubMed或Google Scholar以“PPP1R42 antibody”为关键词筛选最新研究，并优先选择经抗体验证(如KO/KD验证、应用场景明确)的论文。部分研究可能需通过抗体公司(如Abcam、CST)的产品引用文献获取。
**Background of PPP1R42 Antibody**
PPP1R42 (Protein Phosphatase 1 Regulatory Subunit 42) is a regulatory protein that interacts with Protein Phosphatase 1 (PP1), a serine/threonine phosphatase critical for diverse cellular processes, including cell cycle progression, signal transduction, and metabolism. As a regulatory subunit, PPP1R42 modulates PP1’s substrate specificity, enzymatic activity, or subcellular localization, ensuring precise spatiotemporal control of dephosphorylation events.
The PPP1R42 antibody is a tool designed to detect and study the expression, localization, and function of PPP1R42 in biological samples. It is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate PPP1R42’s role in cellular mechanisms. Studies suggest PPP1R42 may be involved in cilia formation and centrosome regulation, linking it to developmental disorders and ciliopathies when dysregulated.
Research utilizing this antibody has expanded insights into PPP1R42’s interaction networks and its potential implications in diseases such as cancer, where PP1 regulatory subunits often exhibit altered expression. The antibody’s specificity is typically validated via knockout/knockdown controls or peptide-blocking assays to ensure accurate detection.
Overall, the PPP1R42 antibody serves as a vital reagent for dissecting PP1-mediated signaling pathways and exploring therapeutic targets in pathologies associated with phosphatase dysregulation.
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