| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LRPB7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human LRRC23 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及LRRC23抗体的研究文献摘要(文献信息为虚构，仅供示例参考)：
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1. **文献名称**: *LRRC23 regulates ciliogenesis through tubulin binding*
**作者**: Smith A, et al. (2021)
**摘要**: 本研究利用抗LRRC23抗体进行免疫共沉淀和免疫荧光实验，发现LRRC23通过与微管蛋白相互作用参与纤毛形成，抗体特异性验证显示其在人类支气管上皮细胞中特异性识别内源性LRRC23蛋白。
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2. **文献名称**: *Antibody-based profiling of LRRC23 in prostate cancer*
**作者**: Chen L, et al. (2019)
**摘要**: 通过开发兔多克隆抗LRRC23抗体，研究者发现LRRC23在前列腺癌组织中表达显著上调，Western blot和IHC实验证实其与肿瘤侵袭性相关，提示其作为潜在生物标志物的可能性。
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3. **文献名称**: *LRRC23 interacts with DNA repair machinery*
**作者**: Tanaka K, et al. (2020)
**摘要**: 使用抗LRRC23抗体的ChIP-seq分析揭示，LRRC23通过结合XPA蛋白参与DNA损伤修复通路，抗体阻断实验进一步验证了其在同源重组修复中的功能必要性。
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注：以上文献为示例性质，实际研究中请通过PubMed或Web of Science检索真实文献。
The LRRC23 (Leucine-Rich Repeat-Containing 23) protein is a member of the leucine-rich repeat (LRR) superfamily, characterized by repetitive structural motifs involved in protein-protein interactions, cellular signaling, and immune responses. LRRC23 is primarily expressed in the testis and is associated with sperm development and function. It has been implicated in the assembly and regulation of the sperm fibrous sheath, a structure critical for sperm motility. Additionally, LRRC23 may play a role in cilia-related processes, linking it to respiratory and reproductive health. Dysregulation of LRRC23 has been explored in studies on male infertility and ciliopathies.
Antibodies targeting LRRC23 are essential tools for investigating its expression, localization, and molecular interactions. They enable researchers to study protein dynamics in sperm maturation, cilia function, and associated pathologies. Commercially available LRRC23 antibodies are typically developed in hosts like rabbits or mice, using immunogenic peptide regions to ensure specificity. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also leverage LRRC23 antibodies to explore its potential as a biomarker for infertility or ciliary disorders. However, validation of antibody specificity remains crucial, given the structural similarities among LRR family proteins. Continued research on LRRC23 and its antibodies may advance understanding of reproductive biology and cilia-related diseases.
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