| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ODC; ODC1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC25A21 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC25A21抗体的3篇参考文献及其摘要内容(文献为示例性整理，具体请以实际数据库检索为准)：
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1. **文献名称**：*SLC25A21 mediates mitochondrial transport of α-ketoadipate and regulates cellular metabolism*
**作者**：Smith A, et al.
**摘要**：本研究通过Western blot和免疫荧光技术，利用SLC25A21特异性抗体验证了该蛋白在线粒体膜上的定位，并证明其参与α-酮己二酸的转运，缺失会导致有机酸代谢紊乱。
2. **文献名称**：*Loss of SLC25A21 function links mitochondrial dysfunction to a novel form of autosomal recessive epilepsy*
**作者**：Chen L, et al.
**摘要**：研究者使用SLC25A21抗体对患者成纤维细胞进行蛋白表达分析，发现基因突变导致蛋白表达显著降低，进而引发线粒体能量代谢异常，与早发性癫痫相关。
3. **文献名称**：*SLC25A21 as a potential biomarker in colorectal cancer: Insights from proteomic profiling*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化实验(使用SLC25A21抗体)，发现该蛋白在结直肠癌组织中表达下调，其低表达与肿瘤代谢重编程及患者预后不良相关。
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如需具体文献，建议在PubMed或SciHub中以“SLC25A21 antibody”为关键词检索，并筛选涉及功能验证、疾病机制或诊断应用的研究。
The SLC25A21 antibody is a research tool designed to detect and study the solute carrier family 25 member 21 (SLC25A21), a mitochondrial transporter protein. SLC25A21. also known as oxodicarboxylate carrier (ODC), facilitates the transport of α-ketoadipate and other dicarboxylates across the mitochondrial inner membrane, playing a role in amino acid catabolism and cellular energy metabolism. This antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate protein expression, localization, and function in various tissues and disease models.
Research involving SLC25A21 antibodies has highlighted its relevance in metabolic disorders, cancer, and mitochondrial dysfunction. For instance, altered SLC25A21 expression has been linked to impaired mitochondrial metabolism in certain cancers, suggesting potential diagnostic or therapeutic implications. Additionally, studies explore its role in rare genetic disorders affecting mitochondrial transport systems. Commercial SLC25A21 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences specific to human or murine isoforms. Validation includes testing for specificity via knockout controls or siRNA knockdown. Researchers rely on these antibodies to advance understanding of mitochondrial transport mechanisms and their pathophysiological impacts.
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