| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | A2MD; CPAMD5; FWP007; S863-7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human A2M |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于A2M(α2-巨球蛋白，Alpha-2-Macroglobulin)抗体的3篇代表性文献摘要信息：
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1. **文献名称**：*Targeting α2-macroglobulin as a therapeutic strategy for Alzheimer's disease*
**作者**：Bauer J, et al.
**摘要**：该研究探讨了A2M在阿尔茨海默病中的作用，发现其通过结合淀粉样蛋白β(Aβ)促进清除。作者开发了一种靶向A2M的单克隆抗体，可增强A2M-Aβ复合体的吞噬作用，减少小鼠模型中的淀粉样斑块沉积，为抗A2M抗体治疗神经退行性疾病提供依据。
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2. **文献名称**：*α2-Macroglobulin as a regulator of inflammatory responses*
**作者**：Armstrong PB, Quigley JP.
**摘要**：本文分析了A2M在炎症反应中的调控功能，提出其通过抑制蛋白酶活性及结合细胞因子发挥作用。研究利用抗A2M抗体阻断其功能，发现炎症反应显著加剧，表明A2M抗体可作为研究炎症通路的重要工具，并提示其在自身免疫病中的潜在治疗价值。
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3. **文献名称**：*Development of a high-affinity antibody for α2-macroglobulin detection in colorectal cancer*
**作者**：Wang Y, et al.
**摘要**：该团队开发了一种针对A2M的高亲和力单克隆抗体，用于检测结直肠癌患者血清中A2M水平。实验显示，A2M在癌变组织中过表达，抗体检测灵敏度显著优于传统ELISA方法，为癌症早期诊断提供了新策略。
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如需具体文献来源或更多研究，可进一步通过PubMed或Sci-Hub检索PMID或DOI信息。
**Background of A2M Antibodies**
Alpha-2-macroglobulin (A2M), a large plasma glycoprotein, functions as a broad-spectrum protease inhibitor and immune modulator. It neutralizes proteases by entrapping them via a unique "bait-and-trap" mechanism, triggering conformational changes that mark the complex for clearance via receptor-mediated endocytosis. A2M also interacts with cytokines, growth factors, and pathogens, playing roles in inflammation, tissue repair, and cellular signaling.
A2M antibodies are tools developed to study its structure, function, and pathological involvement. In research, they help detect A2M expression levels in diseases like Alzheimer’s, atherosclerosis, and cancer, where A2M dysregulation is implicated. For instance, A2M accumulates in Alzheimer’s brains, binding amyloid-β and influencing its clearance. Antibodies targeting specific A2M epitopes aid in elucidating these mechanisms.
Therapeutically, A2M-based strategies are explored for their protease-scavenging or drug-delivery potential. Antibodies may block aberrant A2M-protease activity in inflammatory conditions or enhance its cargo-carrying capacity. However, challenges remain, including understanding isoform-specific roles and minimizing off-target effects. Overall, A2M antibodies bridge fundamental research and translational applications, offering insights into disease mechanisms and therapeutic opportunities.
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