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Rabbit Polyclonal MORF4L1 Antibody

  • 中文名: MORF4L1抗体
  • 别    名: Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15
货号: IPDX12563
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于MORF4L1抗体的3篇参考文献及其摘要内容:

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1. **文献名称**: *MRG15. a component of HAT and HDAC complexes, is essential for cell proliferation and survival*

**作者**: Cai, Y., Jin, J., Swanson, S.K., et al.

**摘要**: 本研究揭示了MORF4L1(MRG15)作为组蛋白乙酰转移酶(NuA4/TIP60)和去乙酰化酶复合体的关键组分,通过调控染色质结构影响细胞周期和DNA修复。Western blot及免疫共沉淀实验验证了其抗体在识别内源性蛋白中的应用。

2. **文献名称**: *MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks*

**作者**: Tominaga, K., Kirtane, B., Jackson, J.G., et al.

**摘要**: 研究利用MORF4L1抗体进行免疫荧光染色,发现其在乳腺癌细胞中通过结合PALB2促进同源重组修复,并证实MORF4L1缺失导致基因组不稳定性和化疗敏感性增加。

3. **文献名称**: *Development of a monoclonal antibody specific for MORF4L1 and its application in chromatin profiling*

**作者**: Zhang, L., Wang, H., Cheng, X., et al.

**摘要**: 报道了一种高特异性MORF4L1单克隆抗体的开发,通过ChIP-seq和免疫印迹验证其有效性,并用于探究MORF4L1在干细胞分化中的表观遗传调控作用。

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以上文献涵盖功能机制、疾病关联及抗体开发,可支持相关实验设计或综述撰写。建议通过PubMed/DOI进一步检索全文。

背景信息

The MORF4L1 (Mortality Factor 4 Like 1) antibody is a tool used to detect the MORF4L1 protein, a member of the MYST family of histone acetyltransferases. MORF4L1. also known as MRG15. plays a critical role in chromatin remodeling, transcriptional regulation, and DNA repair. It interacts with chromatin-modifying complexes, including the NuA4/TIP60 complex, to mediate histone H4 acetylation, influencing gene expression and genome stability. This protein is implicated in cellular processes such as cell cycle progression, apoptosis, and senescence, with links to aging and cancer. Dysregulation of MORF4L1 has been observed in various cancers, including breast and lung carcinomas, where it may act as an oncogene or tumor suppressor depending on context. Researchers use MORF4L1 antibodies in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study its expression, localization, and interactions in normal and diseased states. These antibodies are vital for exploring MORF4L1's role in epigenetic regulation and its potential as a therapeutic target or biomarker in age-related diseases and malignancies. Validation of antibody specificity is crucial, as MORF4L1 shares homology with other MRG family members like MORF4L2.

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