| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AADC |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DDC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于DDC(DOPA脱羧酶)抗体的3篇参考文献的简要概括(注：内容基于公开研究主题模拟，非真实文献)：
1. **文献名称**：*Immunohistochemical Detection of DDC in Neuroendocrine Tumors: A Diagnostic Tool*
**作者**：Smith J, et al.
**摘要**：研究验证了DDC抗体在神经内分泌肿瘤组织中的特异性表达，证实其可作为鉴别诊断标志物，并探讨了抗体在病理学中的应用潜力。
2. **文献名称**：*DOPA Decarboxylase Antibody Characterization in Parkinson's Disease Models*
**作者**：Chen L, Wang H.
**摘要**：通过动物模型分析DDC抗体对多巴胺能神经元的标记效果，发现其在帕金森病中表达降低，提示该抗体可用于疾病机制及药物疗效评估。
3. **文献名称**：*Novel Monoclonal Antibody Targeting DDC for Cancer Therapy*
**作者**：Garcia R, et al.
**摘要**：报道了一种新型抗DDC单克隆抗体的开发，证明其在体外和小鼠模型中可靶向抑制肿瘤细胞增殖，为靶向治疗提供新策略。
4. **文献名称**：*DDC Expression in Drug Metabolism: Insights from Antibody-Based Assays*
**作者**：Tanaka K, et al.
**摘要**：利用DDC抗体研究肝脏和肠道中DDC的分布，揭示其在药物代谢中的作用，为个体化用药提供理论基础。
(注：以上文献信息为示例性模拟，实际引用需以真实数据库检索结果为准。)
Dopa decarboxylase (DDC) antibodies are tools used to study the enzyme DDC, which catalyzes the conversion of L-dopa to dopamine and 5-hydroxytryptophan to serotonin—key neurotransmitters and hormones. DDC is expressed in the brain, liver, kidneys, and neuroendocrine cells, playing roles in neural signaling, blood pressure regulation, and gut motility. Its dysfunction is linked to neurological disorders (e.g., Parkinson’s disease, epilepsy) and neuroendocrine tumors.
DDC antibodies detect and quantify DDC protein levels in research and diagnostics. They are applied in techniques like Western blotting, immunohistochemistry, and ELISA to explore DDC expression patterns in tissues or biofluids. In oncology, these antibodies help identify neuroendocrine tumors, where DDC is often overexpressed. They also aid in studying DDC’s role in neurotransmitter imbalances and drug metabolism.
Commercially available DDC antibodies vary in clonality (monoclonal/polyoclonal) and species reactivity. Validation for specificity and sensitivity is critical, as cross-reactivity with similar enzymes may occur. Recent studies also explore DDC as a potential therapeutic target, with antibodies supporting drug development and mechanistic research. Overall, DDC antibodies bridge basic science and clinical applications, enhancing understanding of diseases linked to dopaminergic and serotonergic pathways.
(Word count: 199)
×
