| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | DEFB-12 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DEFB112 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DEFB112抗体的3篇参考文献示例(注：文献为虚构示例，仅供格式参考)：
1. **文献名称**：*"DEFB112 Expression in Human Reproductive Tissues and Its Role in Antimicrobial Defense"*
**作者**：Zhang Y, et al.
**摘要**：本研究利用DEFB112特异性抗体检测其在睾丸和附睾中的表达，证实DEFB112通过调节先天免疫反应参与生殖道微生物防御。
2. **文献名称**：*"Characterization of DEFB112 Antibody for Detecting Epithelial Immune Responses in Respiratory Infections"*
**作者**：Lee S, et al.
**摘要**：通过Western blot和免疫组化验证DEFB112抗体的特异性，发现DEFB112在呼吸道感染中通过激活TLR4通路增强黏膜屏障功能。
3. **文献名称**：*"DEFB112 as a Potential Biomarker in Prostate Cancer: Antibody-Based Detection and Clinical Implications"*
**作者**：Wang H, et al.
**摘要**：开发了一种高灵敏度DEFB112单克隆抗体，用于分析前列腺癌组织样本，发现DEFB112低表达与肿瘤侵袭性相关。
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“DEFB112 antibody”获取最新研究。
The DEFB112 antibody is designed to detect human beta-defensin 112 (DEFB112), a member of the defensin family of antimicrobial peptides. Beta-defensins are small, cysteine-rich proteins involved in innate immunity, exhibiting broad-spectrum antimicrobial activity and immune modulation. DEFB112 is primarily expressed in epithelial tissues, particularly in the male reproductive tract, suggesting roles in protecting mucosal surfaces and regulating reproductive health. Its gene is located on chromosome 20q11.21. encoding a peptide with a conserved β-defensin structure stabilized by disulfide bonds.
Research on DEFB112 remains limited compared to other defensins, but studies indicate its involvement in host defense, inflammation, and potential roles in fertility. The DEFB112 antibody enables the detection and localization of this protein in biological samples, aiding investigations into its expression patterns under physiological or pathological conditions. It is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study DEFB112's distribution in tissues, secretion pathways, or interactions with microbial or host cells.
Commercial DEFB112 antibodies are typically developed using recombinant protein fragments or synthetic peptides as immunogens. Validation includes specificity testing via knockout controls or blocking assays. Current research focuses on understanding its dual roles in immunity and reproduction, as well as potential associations with infections, inflammatory disorders, or infertility. However, further studies are needed to fully elucidate its mechanisms and clinical relevance.
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