| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BD1; HBD1; DEFB-1; DEFB101 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DEFB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3-4条关于DEFB1(β-防御素1)抗体的参考文献及其摘要概述：
1. **文献名称**: "Human β-defensin 1 in oral squamous cell carcinoma: expression and potential mechanisms"
**作者**: Chen et al. (2018)
**摘要**: 通过免疫组化分析发现，DEFB1在口腔鳞状细胞癌组织中表达显著降低，其抗体用于定位蛋白表达水平，提示DEFB1可能通过调节肿瘤微环境抑制癌症进展。
2. **文献名称**: "β-defensin 1 as a biomarker of chronic respiratory infections"
**作者**: Smith et al. (2020)
**摘要**: 研究利用DEFB1特异性抗体检测呼吸道黏膜样本，发现慢性感染患者DEFB1蛋白水平下降，可能与宿主防御功能受损相关，为治疗提供潜在靶点。
3. **文献名称**: "Epigenetic regulation of DEFB1 in inflammatory skin disorders"
**作者**: Lee & Kim (2019)
**摘要**: 通过Western blot和免疫荧光技术，发现银屑病患者皮肤中DEFB1表达受DNA甲基化调控，其抗体的应用揭示了表观遗传修饰与先天免疫的关联。
4. **文献名称**: "Role of DEFB1 in intestinal mucosal immunity"
**作者**: Müller et al. (2017)
**摘要**: 使用DEFB1抗体进行肠黏膜组织染色，发现炎症性肠病患者DEFB1表达异常，提示其通过调节肠道菌群平衡参与黏膜屏障保护机制。
(注：以上文献信息为示例性内容，实际引用需根据具体研究核实。)
The DEFB1 antibody targets human beta-defensin 1 (DEFB1), a small antimicrobial peptide encoded by the DEFB1 gene. DEFB1 is part of the defensin family, which plays a critical role in innate immunity by providing rapid defense against pathogens, including bacteria, viruses, and fungi. It is constitutively expressed in epithelial tissues, such as the skin, respiratory tract, and urogenital system, and is regulated by inflammatory signals or microbial exposure. DEFB1 disrupts microbial membranes and modulates immune responses by attracting immune cells via chemotactic activity.
DEFB1 antibodies are essential research tools for studying its expression, localization, and function in health and disease. They are used in techniques like immunohistochemistry, Western blotting, and ELISA to investigate DEFB1’s role in infections, inflammatory disorders (e.g., psoriasis, cystic fibrosis), and cancer. Some studies suggest altered DEFB1 levels correlate with disease susceptibility or progression.
These antibodies are typically produced in hosts like rabbits or mice, either as polyclonal or monoclonal forms. Challenges include ensuring specificity due to sequence homology among defensins and optimizing detection in diverse biological samples. Research on DEFB1 continues to explore its therapeutic potential, including as a biomarker or a template for antimicrobial drug design.
×
