| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BD-4; DEFB4; hBD-4; DEFB-4; DEFB104 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DEFB104A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DEFB104A抗体的示例参考文献(内容为模拟示例，实际文献需通过学术数据库验证)：
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1. **标题**：*"Characterization of a Novel Polyclonal Antibody for Human DEFB104A in Epithelial Immunity"*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种针对DEFB104A的多克隆抗体，验证了其在Western blot和免疫组化中的特异性，发现DEFB104A在皮肤和呼吸道黏膜中高表达，提示其在屏障免疫中的作用。
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2. **标题**：*"DEFB104A Expression in Cancer: Role of a Monoclonal Antibody in Tumor Microenvironment Analysis"*
**作者**：Lee H, et al.
**摘要**：通过新型单克隆抗体检测DEFB104A在乳腺癌组织中的表达，发现其与肿瘤相关巨噬细胞浸润相关，可能影响癌症免疫逃逸机制。
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3. **标题**：*"Antibody-Based Detection of DEFB104A in Psoriatic Skin Lesions"*
**作者**：Garcia R, et al.
**摘要**：利用商业化DEFB104A抗体进行免疫荧光分析，证实银屑病皮损中DEFB104A表达显著上调，提示其参与炎症性皮肤病的病理过程。
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4. **标题**：*"DEFB104A Antibody Validation for Flow Cytometry in Immune Cell Subsets"*
**作者**：Wang T, et al.
**摘要**：优化了DEFB104A抗体在流式细胞术中的染色条件，发现其在树突状细胞和中性粒细胞中特异性表达，为免疫细胞功能研究提供工具。
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**建议检索方式**：
- 在PubMed或Google Scholar中搜索关键词：**DEFB104A antibody**、**DEFB104A immunoassay**、**β-defensin 104A antibody**。
- 结合研究领域筛选(如感染、癌症、免疫学等)。
- 注意DEFB104A可能存在的别名(如DEFB4B或β-defensin 4B)。
The DEFB104A antibody targets the human β-defensin 104A (DEFB104A), a member of the β-defensin family involved in innate immunity. β-defensins are small, cationic antimicrobial peptides encoded by the DEFB gene cluster, playing critical roles in microbial defense, wound healing, and immune modulation. DEFB104A, also known as defensin beta 104. is expressed primarily in epithelial tissues, including the skin, respiratory tract, and reproductive organs, where it contributes to barrier function by disrupting microbial membranes and recruiting immune cells via chemotactic signaling. Its expression can be upregulated in response to pathogens or inflammatory stimuli.
Antibodies against DEFB104A are valuable tools for studying its localization, expression patterns, and functional interactions in both healthy and diseased states. They enable researchers to investigate its role in infections, chronic inflammation, and cancers, where defensin dysregulation is often observed. For example, DEFB104A antibodies are used in techniques like Western blotting, immunohistochemistry, or flow cytometry to quantify protein levels or visualize tissue distribution. Additionally, these antibodies aid in exploring DEFB104A’s potential as a biomarker or therapeutic target, particularly in conditions like psoriasis, atopic dermatitis, or certain carcinomas. Commercial DEFB104A antibodies are typically validated for specificity, often through knockout controls or peptide blocking assays, ensuring reliability in experimental settings. Ongoing research continues to unravel its broader immunomodulatory functions, including interactions with receptors like CCR6 and involvement in signaling pathways linked to inflammation.
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