| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CR; CAL2; CAB29 |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CALB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CALB2抗体的3-4条参考文献的简要概述(注：内容为模拟生成，非真实文献)：
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1. **文献名称**：*Calretinin (CALB2) as a Marker for Mesothelial Differentiation: Diagnostic Utility in Pathological Practice*
**作者**：Johnson M, et al.
**摘要**：探讨CALB2抗体在病理诊断中的应用，证实其作为间皮瘤特异性标记物的高敏感性和特异性，并比较其与其他标记物(如WT1)的联合诊断价值。
2. **文献名称**：*Developmental Expression of CALB2 in Murine Cortical Interneurons: Insights into Neuronal Maturation*
**作者**：Wang T, et al.
**摘要**：通过免疫组化分析CALB2在小鼠大脑皮质中间神经元发育中的动态表达，揭示其在神经元成熟和突触形成中的潜在功能。
3. **文献名称**：*Cross-Reactivity of CALB2 Antibodies in Non-Human Primate Models: Implications for Translational Research*
**作者**：Fernandez K, et al.
**摘要**：评估CALB2抗体在非人灵长类动物中的交叉反应性，强调抗体选择对跨物种神经科学研究的重要性，并验证其与人类蛋白的高度保守性。
4. **文献名称**：*CALB2 Downregulation in Temporal Lobe Epilepsy: Correlation with Hippocampal Sclerosis*
**作者**：Nguyen P, et al.
**摘要**：研究颞叶癫痫患者海马组织中CALB2表达降低的现象，提示其可能与神经元丢失和疾病病理机制相关。
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**说明**：上述文献摘要涵盖CALB2抗体的诊断应用(如间皮瘤)、神经发育研究、跨物种比较及疾病机制探索，反映其在基础研究与临床病理中的多样化用途。如需真实文献，建议通过PubMed或Google Scholar搜索关键词“CALB2 antibody”“calretinin diagnostic”等获取。
CALB2 antibody targets calbindin 2. a calcium-binding protein also known as calretinin, encoded by the *CALB2* gene in humans. First identified in the 1980s, calretinin belongs to the EF-hand calcium-binding protein family and shares structural homology with other proteins like calbindin D-28k. It plays a critical role in regulating intracellular calcium levels, influencing neuronal excitability, synaptic plasticity, and cellular protection against calcium overload. Calretinin is predominantly expressed in specific subsets of neurons within the central and peripheral nervous systems, including the retina, cerebral cortex, and enteric ganglia, as well as in non-neuronal tissues like mesothelial cells.
In research and diagnostics, CALB2 antibodies are widely used as immunohistochemical markers. They help identify calretinin-expressing cells in tissue samples, aiding in the diagnosis of mesotheliomas (where calretinin is a positive marker) and distinguishing them from adenocarcinomas. In neuroscience, these antibodies are employed to map neuronal circuits and study conditions like epilepsy, neurodegenerative diseases, and neurodevelopmental disorders linked to calretinin dysfunction. Commercial CALB2 antibodies are typically monoclonal or polyclonal, validated for specificity in applications such as Western blotting, immunofluorescence, and IHC. Their utility in both clinical and experimental settings underscores calretinin's importance in cellular calcium signaling and tissue-specific pathology.
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