| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CLP1; NSR2; SRCL; SCARA4 |
| WB Predicted band size | 82 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human COLEC12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COLEC12抗体的3篇示例参考文献(注：内容为模拟虚构，实际文献需通过学术数据库检索)：
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1. **文献名称**: *"Characterization of a Novel Polyclonal Antibody Against Human COLEC12 and Its Role in Innate Immunity"*
**作者**: Smith A, et al.
**摘要**: 开发了一种针对人COLEC12蛋白的多克隆抗体，验证了其在免疫组化和Western blot中的特异性。研究发现COLEC12在巨噬细胞中高表达，可能通过结合病原体相关分子模式参与先天免疫应答。
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2. **文献名称**: *"COLEC12 Expression in Tumor-Associated Macrophages: A Potential Biomarker for Cancer Progression"*
**作者**: Tanaka K, et al.
**摘要**: 利用抗COLEC12单克隆抗体研究肿瘤微环境中COLEC12的表达模式，发现其与肿瘤相关巨噬细胞的免疫抑制功能相关，提示其作为癌症治疗靶点的潜力。
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3. **文献名称**: *"Structural and Functional Analysis of COLEC12 in Cardiovascular Diseases"*
**作者**: Müller R, et al.
**摘要**: 通过COLEC12抗体检测其在动脉粥样硬化斑块中的分布，发现COLEC12通过调节血管内皮炎症反应参与心血管疾病进程，为治疗提供了新方向。
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如需真实文献，建议使用 **PubMed** 或 **Google Scholar** 检索关键词：
`COLEC12 antibody` `CL-12 immune function` `collectin family antibody`。
COLEC12 (Collectin Subfamily Member 12), also known as CL-P1 (collectin placenta 1), is a transmembrane protein belonging to the C-type lectin superfamily. It functions as a pattern recognition receptor (PRR) in innate immunity, binding to pathogen-associated molecular patterns (PAMPs) like lipopolysaccharides and promoting phagocytosis. Structurally, it contains a collagen-like domain, a neck region, and a carbohydrate-recognition domain (CRD). COLEC12 is expressed in vascular endothelial cells, placental tissue, and immune cells, playing roles in host defense, inflammation modulation, and cellular clearance.
Antibodies targeting COLEC12 are primarily used in research to investigate its expression, localization, and functional mechanisms. They aid in studying its involvement in atherosclerosis, cancer metastasis, and bacterial/viral infections. For example, COLEC12 antibodies have been applied in immunohistochemistry, flow cytometry, and Western blotting to explore its interaction with pathogens or oxidized lipids in vascular diseases. Recent studies also suggest its potential as a therapeutic target, with antibodies being tested for modulating immune responses or drug delivery. However, its precise physiological and pathological roles remain under investigation, necessitating further validation of antibody specificity and functional assays.
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