| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | CX31.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GJB5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于GJB5抗体的3篇模拟参考文献及其摘要概述，供参考：
---
1. **文献名称**: *GJB5 (Connexin 31.3) expression in psoriasis vulgaris: A potential biomarker for epidermal hyperproliferation*
**作者**: Lee S, et al.
**摘要**: 本研究通过免疫组化和Western blot分析，发现GJB5蛋白在银屑病患者表皮层中表达显著上调，提示其可能通过调节角质形成细胞间的缝隙连接通讯参与表皮过度增殖的病理机制，为银屑病的诊断提供潜在标志物。
2. **文献名称**: *Characterization of a novel monoclonal antibody against human GJB5 for functional studies in peripheral neuropathy models*
**作者**: Richardson G, et al.
**摘要**: 文章报道了一种高特异性抗GJB5单克隆抗体的开发与验证，该抗体成功用于检测周围神经损伤小鼠模型中GJB5的动态表达变化，表明其在神经修复过程中可能调控施万细胞的缝隙连接功能。
3. **文献名称**: *GJB5 mutations and altered connexin signaling in squamous cell carcinoma progression*
**作者**: Djalilian AR, et al.
**摘要**: 通过免疫荧光和基因敲除实验，研究发现GJB5在皮肤鳞状细胞癌中表达异常，其突变可能破坏细胞间通讯并促进肿瘤侵袭，提示靶向GJB5信号通路或为癌症治疗新策略。
---
注：以上文献为模拟内容，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实发表论文。如需进一步协助定位文献，可提供更具体的研究方向。
**Background of GJB5 Antibody**
GJB5. encoded by the *GJB5* gene, is a member of the connexin protein family, specifically designated as Connexin 31.1 (Cx31.1). Connexins form gap junctions, which are intercellular channels facilitating direct communication between neighboring cells by allowing the exchange of ions, metabolites, and signaling molecules. These channels play critical roles in maintaining tissue homeostasis, coordinating cellular responses, and regulating processes like epithelial barrier function and neuronal signaling.
GJB5 is a transmembrane protein with four transmembrane domains, contributing to the formation of homomeric or heteromeric gap junction channels. Mutations in *GJB5* have been linked to skin disorders, such as erythrokeratodermia variabilis et progressiva (EKVP), and hearing loss, highlighting its importance in epidermal differentiation and auditory function.
Antibodies targeting GJB5 are essential tools for studying its expression, localization, and function in both normal and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the characterization of GJB5 distribution in tissues such as the epidermis, inner ear, and nervous system. Research using GJB5 antibodies has advanced understanding of connexin-related diseases, mechanisms of cell-cell communication, and potential therapeutic targets. Specificity validation (e.g., knockout controls) ensures reliable results, supporting investigations into GJB5's role in development, disease, and tissue-specific signaling networks.
×
