Rabbit Polyclonal GTF2H1 Antibody

The GTF2H1 antibody is a crucial tool for studying the General Transcription Factor IIH subunit 1 (GTF2H1), a component of the TFIIH complex, which plays essential roles in transcription initiation and nucleotide excision repair (NER). TFIIH is a multi-subunit complex involved in RNA polymerase II-mediated transcription by unwinding DNA at promoter regions and facilitating the transition from initiation to elongation. In DNA repair, it participates in recognizing and repairing bulky DNA lesions, such as those caused by UV radiation. GTF2H1. specifically, stabilizes the complex and regulates its enzymatic activities. Antibodies targeting GTF2H1 enable researchers to investigate its expression, localization, and interactions in cellular processes. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore TFIIH dysfunction linked to diseases, including cancers and genetic disorders like xeroderma pigmentosum. Studies using GTF2H1 antibodies have shed light on transcription-coupled repair mechanisms and transcriptional dysregulation in aging or stress responses. Validation of these antibodies ensures specificity for accurate detection, supporting research into transcriptional regulation, DNA damage responses, and therapeutic targeting of TFIIH-related pathways.