| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ICBP90; C6orf107; dJ349A12.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human UHRF1BP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UHRF1BP1抗体的示例参考文献(注：部分文献为假设性概括，实际引用时请核实来源)：
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1. **文献名称**: "UHRF1BP1 interacts with UHRF1 to regulate DNA methylation and cell cycle progression"
**作者**: Zhang Y, et al.
**摘要**: 本研究通过免疫共沉淀(Co-IP)和Western blot(使用UHRF1BP1抗体)揭示了UHRF1BP1与UHRF1的相互作用，证明两者协同调控DNA甲基化，并影响细胞周期进程，尤其在癌症细胞中异常表达。
2. **文献名称**: "UHRF1BP1 modulates chromatin remodeling in hepatocellular carcinoma"
**作者**: Wang L, et al.
**摘要**: 利用UHRF1BP1抗体进行免疫组化(IHC)和染色质免疫沉淀测序(ChIP-seq)，发现UHRF1BP1在肝癌中过表达，通过改变组蛋白修饰(如H3K9me3)促进肿瘤侵袭性。
3. **文献名称**: "Functional characterization of UHRF1BP1 in embryonic stem cell differentiation"
**作者**: Smith J, et al.
**摘要**: 通过免疫荧光(IF)和流式细胞术(结合特异性抗体)，证明UHRF1BP1在小鼠胚胎干细胞分化中调控多能性基因沉默，影响表观遗传重编程。
4. **文献名称**: "UHRF1BP1 as a novel biomarker in ovarian cancer prognosis"
**作者**: Chen X, et al.
**摘要**: 研究利用UHRF1BP1抗体检测卵巢癌组织中的蛋白表达水平，发现其高表达与患者预后不良相关，提示其作为潜在治疗靶点的价值。
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**注意**：以上文献为示例性内容，实际研究中请通过学术数据库(如PubMed、Web of Science)以“UHRF1BP1 antibody”或“UHRF1BP1 function”为关键词检索最新成果。若需具体文献，可提供发表年份或DOI进一步查询。
The UHRF1BP1 antibody is a research tool designed to detect UHRF1BP1 (Ubiquitin-like with PHD and RING Finger Domains 1 Binding Protein 1), a protein implicated in epigenetic regulation and chromatin remodeling. UHRF1BP1 interacts with UHRF1. a key player in maintaining DNA methylation patterns during replication, suggesting its role in bridging DNA repair, cell cycle control, and epigenetic stability. This protein is broadly expressed in tissues and is linked to cellular processes such as apoptosis, DNA damage response, and transcriptional regulation.
Antibodies targeting UHRF1BP1 are commonly used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to study its expression, localization, and interactions. Research highlights its dysregulation in cancers, including breast and colorectal cancer, where altered UHRF1BP1 levels correlate with tumor progression and poor prognosis. Studies also explore its involvement in neurodevelopmental disorders and autoimmune diseases, though mechanisms remain under investigation.
Commercial UHRF1BP1 antibodies are typically validated for specificity using knockout controls or siRNA knockdowns. Challenges include cross-reactivity due to structural similarities with other ubiquitin-like proteins, necessitating careful validation for experimental accuracy. Current research focuses on elucidating UHRF1BP1’s role in UHRF1-mediated epigenetic pathways and its potential as a therapeutic target. This antibody remains vital for advancing understanding of epigenetic dysregulation in disease contexts.
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