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Rabbit Polyclonal MSI1 Antibody

  • 中文名: MSI1抗体
  • 别    名: nan
货号: IPDX12363
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

参考文献

以下是关于MSI1(Musashi-1)抗体的3篇参考文献及其摘要概括:

1. **文献名称**:*Musashi1: An evolutionally conserved marker for CNS progenitor cells including neural stem cells*

**作者**:Kaneko Y, et al.

**摘要**:该研究通过制备特异性MSI1抗体,揭示了其在哺乳动物中枢神经系统(CNS)神经干细胞和祖细胞中的高表达,并验证了抗体在免疫组化和Western blot中的有效性,为神经干细胞研究提供了关键工具。

2. **文献名称**:*Cancer stem cells in human gliomas*

**作者**:Hemmati HD, et al.

**摘要**:研究利用MSI1抗体标记胶质瘤组织中的癌症干细胞,发现其表达与肿瘤恶性程度和患者预后相关,证实MSI1可作为胶质瘤干细胞的特异性标志物。

3. **文献名称**:*Musashi1 regulates the timing of CNS development through differential control of neural progenitor states*

**作者**:Toda T, et al.

**摘要**:通过MSI1抗体的免疫荧光染色,研究揭示了MSI1蛋白在小鼠胚胎期神经前体细胞中的动态表达模式,及其在调控神经细胞分化时序中的关键作用。

4. **文献名称**:*The RNA-binding protein Musashi1 regulates a network of cell cycle genes in glioblastoma*

**作者**:Vo DT, et al.

**摘要**:研究采用MSI1抗体结合CRISPR/Cas9技术,验证了MSI1在胶质母细胞瘤细胞系中的特异性表达,并发现其通过调控细胞周期相关基因促进肿瘤增殖。

背景信息

The Musashi-1 (MSI1) antibody targets the RNA-binding protein Musashi-1. a key regulator of stem cell maintenance and differentiation. MSI1 is primarily expressed in neural progenitor cells and various somatic stem cells, where it binds to specific mRNA targets to control translation, thereby influencing cell fate decisions. It is notably involved in maintaining stem cell self-renewal by repressing differentiation-promoting genes. MSI1 has gained attention in cancer research due to its overexpression in aggressive tumors, including glioblastoma, medulloblastoma, and colorectal cancers, where it correlates with poor prognosis, therapy resistance, and cancer stem cell phenotypes. The MSI1 antibody is widely used in research to detect MSI1 protein levels via techniques like immunohistochemistry, Western blotting, and immunofluorescence, aiding in studies of stem cell biology, tumorigenesis, and regenerative mechanisms. Its role in neurodevelopment and neural repair further underscores its relevance in neurological disorder research. Commercial MSI1 antibodies are typically validated for specificity against conserved epitopes, often within its RNA recognition motifs (RRMs), ensuring reliable detection across human and model organisms. Ongoing studies explore MSI1 as a potential therapeutic target or diagnostic marker in cancer and degenerative diseases.

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