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Rabbit Polyclonal NCLN Antibody

  • 中文名: NCLN抗体
  • 别    名: NET59
货号: IPDX02774
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

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参考文献

以下是关于NCLN(Nicalin)抗体的模拟参考文献示例(注:部分信息为假设性描述,实际文献需通过学术数据库核实):

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1. **文献名称**: *Nicalin regulates embryonic dorsal-ventral patterning via TGF-β signaling*

**作者**: Haffner C, et al.

**摘要**: 研究揭示了NCLN蛋白通过调节TGF-β信号通路在斑马鱼胚胎背腹轴形成中的关键作用,利用特异性抗体进行免疫共沉淀实验,证实其与TGF-β受体复合物的相互作用。

2. **文献名称**: *Structural insights into Nicalin-mediated protein quality control in the endoplasmic reticulum*

**作者**: Wang L, et al.

**摘要**: 通过冷冻电镜解析NCLN蛋白复合体的三维结构,结合抗体标记技术阐明其在内质网相关降解(ERAD)中对错误折叠蛋白的识别机制。

3. **文献名称**: *Nicalin antibody-based profiling reveals dysregulation in neurodegenerative models*

**作者**: Tanaka K, et al.

**摘要**: 开发了一种高特异性NCLN单克隆抗体,用于阿尔茨海默病模型小鼠脑组织分析,发现NCLN表达水平与tau蛋白异常聚集呈负相关。

4. **文献名称**: *Nicalin modulates Notch signaling through interaction with Nicastrin*

**作者**: Denzel A, et al.

**摘要**: 利用NCLN抗体进行免疫荧光共定位实验,证明NCLN与Nicastrin形成复合物,调控Notch信号通路的活性,影响细胞分化进程。

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建议通过PubMed或Google Scholar以关键词“Nicalin antibody”或“NCLN function”检索真实文献,并优先选择近5年高被引研究。

背景信息

The NCLN antibody is a research tool designed to target Nicalin (NCLN), a conserved transmembrane protein primarily localized in the endoplasmic reticulum (ER). Nicalin plays a critical role in ER-associated processes, including protein complex assembly, signal transduction, and cellular homeostasis. It forms a complex with Nodal modulator (NOMO) and interacts with proteins like TMEM147. influencing pathways such as the Notch signaling cascade, which is vital for embryonic development and cell differentiation. Dysregulation of NCLN has been linked to developmental disorders and cancer progression.

NCLN antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study Nicalin's expression, subcellular localization, and interactions. Researchers employ these antibodies to explore its role in modulating the Notch pathway by regulating the cleavage of ligands such as DLL1. as well as its potential involvement in stress responses and apoptosis. Additionally, NCLN antibodies aid in investigating pathological mechanisms in congenital anomalies or malignancies, where Nicalin's function may be disrupted. Their specificity and reliability make them essential for elucidating NCLN's molecular mechanisms in both physiological and disease contexts.

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