| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IgA1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human IGHA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IGHA1抗体的3篇示例参考文献(文献信息为示例，非真实存在)：
1. **文献名称**: "Structural and functional characterization of human IGHA1 antibodies in mucosal immunity"
**作者**: Smith J, et al.
**摘要**: 该研究解析了IGHA1抗体的分子结构，揭示了其独特的铰链区特征及与黏膜表面分泌成分的结合机制，强调了IGHA1在呼吸道和肠道免疫防御中的关键作用。
2. **文献名称**: "IGHA1 gene polymorphisms and susceptibility to IgA nephropathy"
**作者**: Li X, et al.
**摘要**: 通过全基因组关联分析，发现IGHA1基因特定变异与IgA肾病风险显著相关，提示IGHA1抗体异常糖基化可能参与疾病病理过程。
3. **文献名称**: "Role of IGHA1 in neutralization of enteric pathogens"
**作者**: García-Castillo M, et al.
**摘要**: 实验证明，分泌型IGHA1抗体通过结合霍乱弧菌表面抗原抑制其定植，证实其在肠道病原体中和反应中的特异性保护功能。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如"IGHA1 antibody"、"IgA1 function")获取。推荐参考领域内权威期刊如*Journal of Immunology*、*Mucosal Immunology*近年发表的研究。
IGHA1 (Immunoglobulin Heavy Constant Alpha 1) is a critical component of immunoglobulin A (IgA), the predominant antibody class in mucosal immunity. IgA exists as two subclasses, IgA1 and IgA2. distinguished by structural differences in their heavy chains. IGHA1 forms the constant region of the IgA1 heavy chain, which includes a unique 18-amino acid hinge region rich in proline and serine residues. This flexible hinge allows IgA1 to interact with pathogens and antigens in mucosal environments, such as the respiratory and gastrointestinal tracts.
IgA1 plays a key role in neutralizing pathogens, preventing microbial adhesion to epithelial surfaces, and modulating immune responses. However, its extended hinge region also makes IgA1 susceptible to cleavage by bacterial proteases, contributing to immune evasion in infections. Dysregulation of IgA1 is implicated in diseases like IgA nephropathy (IgAN), where galactose-deficient IgA1 forms immune complexes that deposit in the kidneys, triggering inflammation.
IGHA1-specific antibodies are essential tools in research and diagnostics. They enable quantification of IgA1 levels, detection of abnormal glycosylation patterns in IgAN, and investigation of IgA1's role in autoimmune or inflammatory conditions. These antibodies are widely used in techniques like ELISA, Western blot, and immunohistochemistry to study mucosal immunity, pathogen interactions, and disease mechanisms.
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