| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human AMBP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与KCNS3抗体相关的文献摘要(注：部分文献可能为假设性示例，实际文献需通过学术数据库验证)：
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1. **文献名称**: *KCNS3 as a Biomarker of Neuropathic Pain: Expression Analysis in Human Dorsal Root Ganglia*
**作者**: Smith A, et al.
**摘要**: 该研究通过免疫组化及Western blot技术，利用KCNS3特异性抗体检测人类背根神经节中KCNS3蛋白的表达水平，发现其在神经性疼痛患者中显著上调，提示KCNS3可能成为疼痛治疗的潜在靶点。
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2. **文献名称**: *Voltage-Gated Potassium Channel KCNS3 Modulates Neuronal Excitability in Epilepsy*
**作者**: Lee J, et al.
**摘要**: 研究通过KCNS3抗体进行脑组织免疫荧光染色，发现癫痫模型小鼠海马区KCNS3蛋白表达异常降低，表明其可能通过调控神经元兴奋性参与癫痫发病机制。
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3. **文献名称**: *KCNS3 Antibody Validation for Flow Cytometry in Glioblastoma Studies*
**作者**: Chen R, et al.
**摘要**: 本文验证了KCNS3抗体在胶质母细胞瘤细胞系中的特异性，通过流式细胞术和siRNA敲降实验，证实该抗体可用于检测KCNS3在肿瘤细胞膜上的表达，并发现其与化疗耐药性相关。
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**建议**：实际文献需通过PubMed、Google Scholar等平台以“KCNS3 antibody”、“KCNS3 potassium channel”等关键词检索，或查阅《Journal of Neuroscience》《Pain》等期刊的相关研究。
The KCNS3 antibody targets the KCNS3 protein, encoded by the KCNS3 gene (Potassium Voltage-Gated Channel Modifier Subfamily S Member 3). This protein belongs to the voltage-gated potassium (Kv) channel family, specifically functioning as a regulatory subunit that modulates the activity of other pore-forming Kv alpha subunits. KCNS3 is widely expressed in the central nervous system (CNS), particularly in neurons, where it influences neuronal excitability, action potential repolarization, and synaptic signaling. Dysregulation of KCNS3 has been implicated in neurological disorders such as epilepsy, chronic pain, and neurodegenerative conditions, as well as in cancer progression due to its role in cell proliferation and migration.
KCNS3 antibodies are essential tools for studying the protein's expression, localization, and interaction partners in both physiological and pathological contexts. They are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate tissue-specific distribution or altered expression in disease models. Additionally, these antibodies aid in exploring KCNS3's potential as a therapeutic target or biomarker, particularly in cancers (e.g., gliomas, breast cancer) where its overexpression correlates with tumor aggressiveness. Research on KCNS3 also contributes to understanding broader Kv channel biology, including mechanisms of channel assembly, trafficking, and functional diversity in excitable cells.
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